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Igama lemveliso |
Gs441524 |
Imbonakalo |
White powder,pill,liquid type |
Isivavanyi |
>99% |
Uvavanyo |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Ubushushu boGcino |
Indawo eyomileyo epholileyo |
Intshayelelo
I-GS-441524 licandelo lebhayoloji elisebenzayo le-Remdesivir kwaye ibisetyenziswa kakhulu kwihlabathi jikelele ukunyanga ngokukhuselekileyo nangempumelelo iikati ze-feline infectious peritonitis (FlP) ngaphezulu kweenyanga ezili-18. I-FIP sisifo esiqhelekileyo nesibulala kakhulu kwiikati.
Umsebenzi
I-GS-441524 yi-molecule encinci enegama lesayensi le-nucleoside triphosphate competitive inhibitor, ebonisa umsebenzi onamandla we-antiviral ngokuchasene neentsholongwane ezininzi ze-RNA. Isebenza njengenye i-substrate kunye ne-RNA chain terminator ye-RNA exhomekeke kwi-RNA polymerase yentsholongwane. I-concentration engeyona ityhefu ye-GS-441524 kwiiseli ze-feline iphezulu njenge-100, ethintela ngokufanelekileyo ukuphindaphinda kwe-FIPV kwinkcubeko yeseli ye-CRFK kunye ne-cat peritoneal macrophages eyosulelwe ngokwemvelo kunye noxinzelelo oluphantsi njenge-1.
Umbuzo: Yintoni i-GS?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Okwangoku iyafumaneka njengenaliti okanye iyeza lomlomo nangona inguqulelo yomlomo ayikafumaneki ngokubanzi okwangoku. Ndicela ubuza admin!
Umbuzo: Lude kangakanani unyango?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Umbuzo: Ndizikhupha njani iinaliti ze-GS?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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