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Ainm toraidh |
Gs441524 |
Coltas |
White powder,pill,liquid type |
Assay |
> 99% |
Deuchainn |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Teòthachd stòraidh |
Àite tioram fionnar |
Ro-ràdh
Tha GS-441524 na phàirt gnìomhach bith-eòlasach de Remdesivir agus chaidh a chleachdadh gu farsaing air feadh an t-saoghail gus cait de peritonitis gabhaltach feline (FlP) a leigheas gu sàbhailte agus gu h-èifeachdach airson còrr air 18 mìosan. Tha FIP na ghalar cumanta agus gu math marbhtach ann an cait.
Gnìomh
Tha GS-441524 na mholacile beag le ainm saidheansail de inhibitor farpaiseach nucleoside triphosphate, a tha a ’nochdadh gnìomhachd anti-bhìoras làidir an aghaidh mòran bhìorasan RNA. Bidh e na substrate eile agus inneal-crìochnachaidh slabhraidh RNA airson RNA polymerase viral a tha an urra ri RNA. Tha an dùmhlachd neo-phuinnseanta de GS-441524 ann an ceallan feline cho àrd ri 100, a tha gu h-èifeachdach a’ bacadh ath-riochdachadh FIPV ann an cultar cealla CRFK agus macrophages peritoneal cat le galair nàdarra le dùmhlachd cho ìosal ri 1.
C: Dè a th' ann an GS?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Tha e an-dràsta ri fhaighinn mar in-stealladh no cungaidh-leigheis beòil ged nach eil an dreach beòil ri fhaighinn fhathast gu farsaing. Feuch an iarr thu air rianaire!
C: Dè cho fada 'sa tha an làimhseachadh?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
C: Ciamar a bheir mi na stealladh GS?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
Pacadh:
- le poca no bogsa carton
PS: tha sinn a 'gabhail ri gnàthachadh pacaidh.
Luingearachd:
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