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اسم المنتج |
GS441524 |
مظهر |
White powder,pill,liquid type |
فحص |
> 99٪ |
امتحان |
HPLC |
CAS |
1191237-69-0 |
مف |
C12H13N5O4 |
درجة حرارة التخزين |
مكان بارد وجاف |
مقدمة
GS-441524 هو المكون النشط بيولوجيًا في Remdesivir وقد استخدم على نطاق واسع في جميع أنحاء العالم لعلاج القطط من التهاب الصفاق المعدي (FlP) بأمان وفعالية لأكثر من 18 شهرًا. FIP هو مرض شائع ومميت للغاية للقطط.
وظيفة
GS-441524 هو جزيء صغير يحمل اسمًا علميًا للمثبط التنافسي للنيوكليوزيد ثلاثي الفوسفات ، والذي يُظهر نشاطًا قويًا مضادًا للفيروسات ضد العديد من فيروسات الحمض النووي الريبي. إنه بمثابة ركيزة بديلة وإنهاء سلسلة RNA للفيروس RNA المعتمد على بوليميراز RNA. يصل التركيز غير السام لـ GS-441524 في خلايا القطط إلى 100 ، مما يمنع بشكل فعال تكاثر FIPV في مزرعة خلايا CRFK والضامة البريتونية المصابة بشكل طبيعي مع تركيز منخفض يصل إلى 1.
س: ما هو GS؟
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
يتوفر حاليًا كحقن أو دواء عن طريق الفم على الرغم من أن النسخة الفموية لا تزال غير متوفرة على نطاق واسع حتى الآن. من فضلك اسأل مسؤول!
س: ما هي مدة العلاج؟
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
س: كيف أعطي حقن GS؟
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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