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Lebitso la Sehlahiswa |
Gs441524 |
Ponahalo |
White powder,pill,liquid type |
Tlhahlobo |
>99% |
Teko |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Mocheso oa polokelo |
Cool Dry Place |
Selelekela
GS-441524 ke motsoako o sebetsang oa bioloji oa Remdesivir mme esale e sebelisoa lefatšeng ka bophara ho phekola ka mokhoa o sireletsehileng le ka katleho likatse tsa feline infectious peritonitis (FlP) ka nako e fetang likhoeli tse 18. FIP ke lefu le tloaelehileng le le bolaeang haholo la likatse.
Mosebetsi
GS-441524 ke molek'hule e nyane e nang le lebitso la saense la nucleoside triphosphate competitive inhibitor, e bonts'ang ts'ebetso e matla ea antiviral khahlano le livaerase tse ngata tsa RNA. E sebetsa e le karolo e 'ngoe ea substrate le terminator ea RNA bakeng sa RNA polymerase e itšetlehileng ka vaerase. Motsoako o senang chefo oa GS-441524 liseleng tsa nama e phahame ho feta 100, e thibelang phetiso ea FIPV ka mokhoa o atlehileng moetlong oa lisele tsa CRFK le li-macrophages tsa cat peritoneal tse nang le tšoaetso ka tlhaho tse tlase joalo ka 1.
P: GS ke eng?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Hajoale e fumaneha e le ente kapa moriana o nooang le hoja mofuta oa molomo o ntse o e-so fumanehe ka bongata. Ke kopa o botse admin!
P: Kalafo e nka nako e kae?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
P: Ke fana ka liente tsa GS joang?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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