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Jina la bidhaa |
Gs441524 |
Mwonekano |
White powder,pill,liquid type |
Uchambuzi |
>99% |
Mtihani |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Joto la Uhifadhi |
Mahali Penye Baridi Kavu |
Utangulizi
GS-441524 ni kijenzi amilifu cha kibayolojia cha Remdesivir na imekuwa ikitumika kote ulimwenguni kuponya paka wa ugonjwa wa peritonitis ya kuambukiza (FlP) kwa zaidi ya miezi 18. FIP ni ugonjwa wa kawaida na mbaya sana wa paka.
Kazi
GS-441524 ni molekuli ndogo yenye jina la kisayansi la kizuizi cha ushindani cha nucleoside triphosphate, ambayo inaonyesha shughuli kali ya antiviral dhidi ya virusi vingi vya RNA. Hutumika kama substrate mbadala na kiondoa mnyororo wa RNA kwa polimasi ya RNA inayotegemea RNA. Mkusanyiko usio na sumu wa GS-441524 katika seli za paka ni wa juu hadi 100, ambayo huzuia kwa ufanisi ujirudiaji wa FIPV katika utamaduni wa seli za CRFK na sehemu kuu za peritoneal za paka zilizoambukizwa kwa asili na mkusanyiko wa chini kama 1.
Swali: GS ni nini?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Kwa sasa inapatikana kama sindano au dawa ya kumeza ingawa toleo la kumeza bado halijapatikana kwa wingi. Tafadhali niulize admin!
Swali: Matibabu ni ya muda gani?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Swali: Je, ninatoaje sindano za GS?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
Ufungashaji:
- kwa begi au sanduku la katoni
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