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Nome di u produttu |
Gs441524 |
Apparizione |
White powder,pill,liquid type |
Assai |
> 99% |
Testu |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Temperature di almacenamiento |
Cool Dry Place |
Introduzione
GS-441524 hè u cumpunente biologicu attivu di Remdesivir è hè statu largamente utilizatu in u mondu per curà in modu sicuru è efficace i misgi di peritonite infettiva felina (FlP) per più di 18 mesi. FIP hè una malatia cumuni è altamente fatale di i misgi.
Funzione
GS-441524 hè una piccula molécula cù un nome scientificu di inhibitore competitivu di nucleoside triphosphate, chì mostra una forte attività antivirale contr'à parechji virus RNA. Serve cum'è un sustrato alternativu è un terminatore di a catena di RNA per l'RNA polimerasi virali dipendente da RNA. A cuncentrazione non tossica di GS-441524 in e cellule feline hè altu cum'è 100, chì inibisce in modu efficace a replicazione di FIPV in a cultura di cellule CRFK è i macrofagi peritoneali di gatti infettati naturalmente cù una cuncentrazione quant'è 1.
Q: Cosa hè GS?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Hè attualmente dispunibule cum'è una iniezione o una medicazione orale, ancu s'è a versione orale ùn hè ancu largamente dispunibule. Per piacè dumandate à un amministratore!
Q: Quantu dura u trattamentu?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Q: Cumu dà l'injections GS?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
imballaggio:
- per saccu o scatula di cartone
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spedizione:
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