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商品名 |
Gs441524 |
外観 |
White powder,pill,liquid type |
アッセイ |
>99% |
テスト |
HPLC |
キャス |
1191237-69-0 |
MF |
C12H13N5O4 |
保管温度 |
涼しい乾燥した場所 |
序章
GS-441524 はレムデシビルの生物学的に活性な成分であり、ネコ伝染性腹膜炎 (FlP) の猫を安全かつ効果的に治療するために 18 か月以上にわたって世界中で広く使用されてきました。 FIPは、猫によくみられる致命的な病気です。
関数
GS-441524はヌクレオシド三リン酸競合阻害剤の学名を持つ低分子で、多くのRNAウイルスに対して強力な抗ウイルス活性を示します。これは、ウイルス RNA 依存性 RNA ポリメラーゼの代替基質および RNA チェーン ターミネーターとして機能します。ネコ細胞における GS-441524 の非毒性濃度は 100 と高く、CRFK 細胞培養および自然に感染したネコの腹腔マクロファージにおける FIPV 複製を 1 という低い濃度で効果的に阻害します。
Q:GSとは何ですか?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
現在、注射または経口薬として利用できますが、経口バージョンはまだ広く利用できません.管理人に聞いてください!
Q:治療期間はどのくらいですか?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Q: GS 注射はどのように行うのですか?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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