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Mahsulot nomi |
Gs441524 |
Tashqi ko'rinish |
White powder,pill,liquid type |
Tahlil |
>99% |
Sinov |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Saqlash harorati |
Salqin quruq joy |
Kirish
GS-441524 Remdesivirning biologik faol komponenti bo'lib, 18 oydan ortiq vaqt davomida mushuklarni yuqumli peritonit (FlP) dan xavfsiz va samarali davolash uchun butun dunyoda keng qo'llanilgan. FIP - bu mushuklarning keng tarqalgan va o'limga olib keladigan kasalligi.
Funktsiya
GS-441524 nukleosid trifosfat raqobatbardosh inhibitori ilmiy nomiga ega bo'lgan kichik molekula bo'lib, u ko'plab RNK viruslariga qarshi kuchli antiviral faollikni ko'rsatadi. Virusli RNKga bog'liq RNK polimeraza uchun muqobil substrat va RNK zanjiri terminatori bo'lib xizmat qiladi. Mushuk hujayralarida GS-441524 ning toksik bo'lmagan kontsentratsiyasi 100 ga teng, bu CRFK hujayra madaniyatida va tabiiy infektsiyalangan mushuk peritoneal makrofaglarida FIPV replikatsiyasini samarali ravishda inhibe qiladi.
Savol: GS nima?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Hozirgi vaqtda u in'ektsiya yoki og'iz orqali yuboriladigan dori sifatida mavjud, ammo og'zaki versiyasi hali keng tarqalgan emas. Iltimos admindan so'rang!
Savol: Davolanish qancha davom etadi?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Savol: GS in'ektsiyalarini qanday qilishim mumkin?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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