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Khoom npe |
wb 441524 |
Qhov tshwm sim |
White powder,pill,liquid type |
Assay |
> 99% |
Kuaj |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Cia Kub |
Txias qhov chaw qhuav |
Taw qhia
GS-441524 yog cov tshuaj lom neeg lom neeg ntawm Remdesivir thiab tau siv dav thoob ntiaj teb kom muaj kev nyab xeeb thiab zoo kho miv ntawm feline kis kab mob peritonitis (FlP) rau ntau tshaj 18 lub hlis. FIP yog ib yam kab mob uas tshwm sim thiab tuag taus ntawm miv.
Muaj nuj nqi
GS-441524 yog ib qho me me molecule nrog lub npe tshawb fawb ntawm nucleoside triphosphate kev sib tw inhibitor, uas qhia tau hais tias muaj zog tiv thaiv kab mob tiv thaiv ntau tus kab mob RNA. Nws ua hauj lwm ua lwm yam substrate thiab RNA saw terminator rau kab mob RNA-dependent RNA polymerase. Qhov tsis muaj tshuaj lom neeg concentration ntawm GS-441524 hauv feline hlwb yog siab li 100, uas zoo inhibits FIPV replication hauv CRFK cell kab lis kev cai thiab ib txwm muaj kab mob miv peritoneal macrophages nrog ib tug concentration tsawg li 1.
Q: GS yog dab tsi?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Nws yog tam sim no muaj nyob rau hauv kev txhaj tshuaj lossis tshuaj noj hauv qhov ncauj txawm hais tias qhov ncauj version tseem tsis tau muaj dav. Thov nug tus admin!
Q: Kev kho mob ntev npaum li cas?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Q: Kuv yuav muab cov tshuaj GS li cas?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
Ntim:
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