GS-441524 Kwa Mphaka FIPV

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Dzina la malonda:GS-441524 Kagwiritsidwe: mphaka fipv Madzi:20mg/ml,30mg/ml 6ml/botolo, 7ml/vial,8ml/botolo, 10ml/botolo Mapiritsi:5mg,10mg,20mg,25mg,40mg,50mg,60mg per piritsi kapena malinga ndi zofuna za makasitomala.

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Tsatanetsatane

Tags

Dzina lazogulitsa	Gs441524
Maonekedwe	ufa woyera, piritsi, mtundu wamadzimadzi
Kuyesa	> 99%
Yesani	Mtengo wa HPLC
CAS	1191237-69-0
MF	C12H13N5O4
Kutentha Kosungirako	Malo Ozizira Owuma

Mawu Oyamba
GS-441524 ndi gawo lachilengedwe la Remdesivir ndipo lakhala likugwiritsidwa ntchito padziko lonse lapansi kuchiza amphaka a feline infectious peritonitis (FlP) kwa miyezi yopitilira 18. FIP ndi matenda ofala komanso oopsa kwambiri amphaka.

Ntchito
GS-441524 ndi kamolekyu kakang'ono kamene kamakhala ndi dzina lasayansi la nucleoside triphosphate competitive inhibitor, yomwe imawonetsa mphamvu zolimbana ndi ma virus ambiri a RNA. Imagwira ngati gawo laling'ono komanso choyimira cha RNA cha ma virus omwe amadalira RNA polymerase. Kuphatikizika kopanda poizoni kwa GS-441524 m'maselo amkaka ndipamwamba kwambiri mpaka 100, komwe kumalepheretsa kubwereza kwa FIPV mu CRFK cell cell komanso macrophages amphaka omwe ali ndi kachilombo koyambitsa matenda omwe amakhala otsika kwambiri mpaka 1.

Q: Kodi GS ndi chiyani?
A: GS ndi yochepa kwa GS-441524 yomwe ndi mankhwala oyesera oletsa tizilombo toyambitsa matenda (nucleoside analog) omwe adachiritsa amphaka ndi FIP m'mayesero a m'munda omwe amachitidwa ku UC Davis koma Dr. Neils Pedersen ndi gulu lake. Onani phunziro apa.
Pakali pano ikupezeka ngati jekeseni kapena mankhwala apakamwa ngakhale kuti oral version sichinapezekebe. Chonde funsani admin!
Q: Kodi mankhwalawa ndi otalika bwanji?
A: Chithandizo chovomerezeka chochokera ku mayesero oyambirira a Dr. Pedersen ndi osachepera masabata a 12 a jakisoni wa subcutaneous tsiku lililonse.
Magazi amayenera kuyang'aniridwa kumapeto kwa masabata 12 ndipo zizindikiro za mphaka ziyenera kuyesedwa kuti muwone ngati pakufunika chithandizo china.

Q: Kodi kwenikweni milandu ya "neuro" kapena "ocular" ndi chiyani?
A: "Neuro" mphaka amatanthauza kuti FIP yadutsa chotchinga muubongo wamagazi ndipo zizindikiro zimaphatikizapo zovuta zamanjenje. Ataxia (kufooka m'miyendo yanga yakumbuyo makamaka), kulephera kudumpha mokwanira popanda kukayikira, kusowa kwa mgwirizano ndi khunyu zimatha kuchitika. Kukhudzidwa kwa maso, komwe kumakhala kofala ndi mawonekedwe a minyewa popeza maso ndi ubongo zimalumikizana kwambiri, zikuwoneka motere:

Q: Kodi ndingapereke bwanji jakisoni wa GS?
Yankho: jakisoni amaperekedwa pansi pa khungu kapena "sub-cu" kutanthauza pansi pa khungu. Ma jakisoni ayenera kuperekedwa maola 24 aliwonse nthawi yofanana tsiku lililonse momwe zingathere kwa milungu 12. Singano isalowe mu minofu ya mphaka. GS imaluma pa jakisoni koma ululu utatha jekeseniyo ikangotha. Pali makanema othandiza angapo omwe mamembala athu adayika akuwonetsa momwe amabatsira komanso ambiri pa YouTube. Ndibwino kuti veterinarian wanu akupatseni jakisoni woyamba kapena awiri ndikukuphunzitsani momwe mungawachitire. Ma Kit omwe ndi ovuta kuwaletsa kuwombera angafunike kupita kwa vet tsiku ndi tsiku

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