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tên sản phẩm |
Gs441524 |
Vẻ bề ngoài |
White powder,pill,liquid type |
xét nghiệm |
>99% |
Bài kiểm tra |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Nhiệt độ bảo quản |
Nơi khô mát |
Giới thiệu
GS-441524 là thành phần có hoạt tính sinh học của Remdesivir và đã được sử dụng rộng rãi trên toàn thế giới để chữa bệnh viêm phúc mạc truyền nhiễm ở mèo (FlP) một cách an toàn và hiệu quả trong hơn 18 tháng. FIP là một bệnh phổ biến và gây tử vong cao ở mèo.
Chức năng
GS-441524 là một phân tử nhỏ có tên khoa học là chất ức chế cạnh tranh nucleoside triphosphate, cho thấy hoạt tính kháng vi-rút mạnh đối với nhiều loại vi-rút RNA. Nó phục vụ như một cơ chất thay thế và chất kết thúc chuỗi RNA cho RNA polymerase phụ thuộc RNA của virus. Nồng độ không độc hại của GS-441524 trong tế bào mèo cao tới 100, ức chế hiệu quả quá trình sao chép FIPV trong nuôi cấy tế bào CRFK và đại thực bào phúc mạc mèo bị nhiễm bệnh tự nhiên với nồng độ thấp tới 1.
Hỏi: GS là gì?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Nó hiện có sẵn dưới dạng thuốc tiêm hoặc thuốc uống mặc dù phiên bản uống vẫn chưa được phổ biến rộng rãi. Xin hỏi admin!
Hỏi: Thời gian điều trị là bao lâu?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Q: Tôi tiêm GS như thế nào?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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