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наименование товара |
Гс441524 |
Появление |
White powder,pill,liquid type |
анализ |
>99% |
Тест |
ВЭЖХ |
КАС |
1191237-69-0 |
МФ |
C12H13N5O4 |
Температура хранения |
Прохладное сухое место |
Введение
GS-441524 является биологически активным компонентом Ремдесивира и уже более 18 месяцев широко используется во всем мире для безопасного и эффективного лечения кошек от кошачьего инфекционного перитонита (FLP). FIP является распространенным и очень фатальным заболеванием кошек.
Функция
GS-441524 представляет собой небольшую молекулу с научным названием конкурентного ингибитора нуклеозидтрифосфата, который проявляет сильную противовирусную активность против многих РНК-содержащих вирусов. Он служит альтернативным субстратом и терминатором цепи РНК для вирусной РНК-зависимой РНК-полимеразы. Нетоксичная концентрация GS-441524 в кошачьих клетках достигает 100, что эффективно ингибирует репликацию FIPV в культуре клеток CRFK и естественно инфицированных перитонеальных макрофагах кошки при концентрации всего 1.
В: Что такое ГС?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
В настоящее время он доступен в виде инъекционного или перорального препарата, хотя пероральная версия еще не получила широкого распространения. Пожалуйста, спросите администратора!
В: Как долго длится лечение?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
В: Как мне делать инъекции GS?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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