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Nama Produk |
Gs441524 |
Penampilan |
White powder,pill,liquid type |
Ujian |
>99% |
Ujian |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Suhu Penyimpanan |
Tempat Kering yang Sejuk |
pengenalan
GS-441524 ialah komponen biologi aktif Remdesivir dan telah digunakan secara meluas di seluruh dunia untuk menyembuhkan kucing peritonitis berjangkit (FlP) kucing dengan selamat dan berkesan selama lebih 18 bulan. FIP adalah penyakit kucing yang biasa dan sangat membawa maut.
Fungsi
GS-441524 ialah molekul kecil dengan nama saintifik perencat kompetitif nukleosida trifosfat, yang menunjukkan aktiviti antivirus yang kuat terhadap banyak virus RNA. Ia berfungsi sebagai substrat alternatif dan penamat rantai RNA untuk polimerase RNA yang bergantung kepada RNA virus. Kepekatan bukan toksik GS-441524 dalam sel kucing adalah setinggi 100, yang berkesan menghalang replikasi FIPV dalam kultur sel CRFK dan makrofaj peritoneal kucing yang dijangkiti secara semula jadi dengan kepekatan serendah 1.
S: Apakah GS?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Ia kini boleh didapati sebagai suntikan atau ubat oral walaupun versi oral masih belum tersedia secara meluas lagi. Sila tanya admin!
S: Berapa lama rawatan?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
S: Bagaimanakah cara saya memberi suntikan GS?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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