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productnaam |
Gs441524 |
Verschijning |
White powder,pill,liquid type |
Test |
>99% |
Test |
HPLC |
CAS |
1191237-69-0 |
MF |
C12H13N5O4 |
Bewaar temperatuur |
Koele droge plaats |
Invoering
GS-441524 is het biologisch actieve bestanddeel van Remdesivir en wordt al meer dan 18 maanden op grote schaal gebruikt over de hele wereld om katten veilig en effectief te genezen van feliene infectieuze peritonitis (FlP). FIP is een veel voorkomende en zeer dodelijke ziekte bij katten.
Functie
GS-441524 is een klein molecuul met een wetenschappelijke naam van nucleosidetrifosfaat-competitieve remmer, die sterke antivirale activiteit vertoont tegen veel RNA-virussen. Het dient als alternatief substraat en RNA-ketenterminator voor viraal RNA-afhankelijk RNA-polymerase. De niet-toxische concentratie van GS-441524 in kattencellen is zo hoog als 100, wat FIPV-replicatie effectief remt in CRFK-celkweek en natuurlijk geïnfecteerde kattenperitoneale macrofagen met een concentratie zo laag als 1.
Vraag: Wat is GS?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
Het is momenteel verkrijgbaar als injectie of als oraal medicijn, hoewel de orale versie nog niet overal verkrijgbaar is. Vraag het een beheerder!
Vraag: Hoe lang duurt de behandeling?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.
Q: What exactly are “neuro” or “ocular” cases?
A: “Neuro” cat means that FIP has crossed the blood brain barrier and symptoms include central nervous system issues. Ataxia (weakness in my back legs especially), inability to jump fully without hesitation, lack of coordination and seizures may occur. Ocular involvement, which is common with the neurological form since the eyes and brain are closely connected, looks like this:
Vraag: Hoe geef ik de GS-injecties?
A: The injections are given sub-cutaneously or “sub-cu” which means just under the skin. Injections are to be given every 24 hours at as close to the same time everyday as is possible for at least 12 weeks. The needle should NOT poke into the muscle of the cat. The GS stings upon injection but the pain is over as soon as the injection is over. There are several helpful videos that our members have posted showing how they inject and also many on YouTube. It’s best to have your vet do the first injection or two and to teach you how to do them. Kitties that are more difficult to restrain for the shots may require daily trips to the vet
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