GS-441524 ee bisad FIPV

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Magaca badeecada: GS-441524 Isticmaalka: bisad fipv Dareere:20mg/ml,30mg/ml 6ml/fijaale, 7ml/vial,8ml/fijaale, 10ml/kiniiniga dhalada:5mg,10mg,20mg,25mg,40mg,50mg,60mg per kaniiniga ama sida waafaqsan shuruudaha macaamiisha.

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Tags

Magaca Alaabta	Gs441524
Muuqashada	Budada cad, kaniiniga, nooca dareeraha
Qiimayn	>99%
Tijaabi	HPLC
CAS	1191237-69-0
MF	C12H13N5O4
Heerkulka Kaydinta	Meel qallalan oo qabow

Hordhac
GS-441524 waa qaybta firfircoon ee bayooloji ee Remdesivir waxaana si weyn looga isticmaali jiray adduunka oo dhan si ammaan ah oo waxtar leh loogu daweeyo bisadaha peritonitis-ka feline infekshanka (FlP) in ka badan 18 bilood. FIP waa cudur caadi ah oo aad u dilaa ah bisadaha.

Shaqada
GS-441524 waa unug yar oo leh magac saynis ah oo ah nucleoside triphosphate inhibitor, kaas oo muujinaya firfircoonida fayraska ka hortagga fayraska badan ee RNA. Waxay u adeegtaa sidii substrate ka duwan iyo joojinta silsiladda RNA ee fayraska RNA-ku-tiirsanaanta RNA polymerase. Isku-dhafka aan sunta ahayn ee GS-441524 ee unugyada feline-ka ayaa ah mid aad u sarreeya sida 100, taas oo si wax ku ool ah u joojinaysa ku-noqoshada FIPV ee dhaqanka unugyada CRFK iyo macrophages bisadaha dabiiciga ah ee cudurka qaba oo leh feejignaan sida ugu hooseeya 1.

S: Waa maxay GS?
J: GS waxay u soo gaabisay GS-441524 taas oo ah daawada tijaabada ah ee ka hortagga fayraska (nucleoside analogue) kaas oo daaweeyay bisadaha leh FIP ee tijaabooyinka goobta lagu sameeyay UC Davis laakiin Dr. Neils Pedersen iyo kooxdiisa. Halkan ka eeg daraasadda.
Hadda waxa loo heli karaa irbad ahaan ama dawo afka laga qaato in kasta oo nooca afka laga qaato aan weli si ballaadhan loo helin. Fadlan weydii admin!
S: Ilaa intee ayay daawadu jirtaa?
J: Daawaynta lagu taliyay ee ku salaysan tijaabadii asalka ahayd ee Dr. Pedersen waa ugu yaraan 12 toddobaad oo irbado maqaarka hoostiisa ah oo maalinle ah.
Shaqada dhiiga waa in la hubiyaa dhamaadka 12ka usbuuca waana in la qiimeeyaa calamadaha bisadaha si loo eego hadii loo baahan yahay daaweyn dheeraad ah.

S: Waa maxay dhab ahaan kiisaska "neuro" ama "ocular"?
J: Bisad "Neuro" macnaheedu waa in FIP ay ka gudubtay xannibaadda maskaxda ee dhiigga calaamadaha waxaa ka mid ah arrimaha habdhiska dhexe ee neerfayaasha. Ataxia (daciifnimada lugaha dhabarka gaar ahaan), awood la'aanta inaan si buuxda u boodo cabsi la'aan, la'aan la'aan iyo suuxdin ayaa dhici karta. Ku lug lahaanshaha indhaha, oo ku badan qaabka neerfaha maadaama indhaha iyo maskaxda ay si dhow isugu xiran yihiin, waxay u egtahay sidan:

S: Sideen ku siinayaa cirbadaha GS?
J: Duritaannada waxaa lagu bixiyaa maqaarka hoostiisa ama "sub-cu" oo macnaheedu yahay maqaarka hoostiisa. Cirbadaha waa in la qaataa 24-kii saacba waqti isku mid ah maalin kasta sida ugu macquulsan ugu yaraan 12 toddobaad. Irbaddu waa inaanay ku dhicin muruqa bisadda. GS waxay ku qancaa duritaanka laakiin xanuunku wuu dhamaanayaa isla marka cirbadadu dhamaato. Waxaa jira dhowr muuqaal oo waxtar leh oo xubnaheenu soo dhejiyeen oo muujinaya sida ay u duraan iyo waliba qaar badan oo YouTube ka ah. Way fiicantahay in dhakhtarkaagu ku sameeyo duritaanka koowaad ama laba oo ku baro sida loo sameeyo. Kitties ay aad ugu adag tahay in la xakameeyo tallaalada ayaa laga yaabaa inay u baahdaan safar maalinle ah oo dhakhtarka xoolaha ah

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