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  • I-GS-441524 licandelo lebhayoloji elisebenzayo le-Remdesivir

Mar. 19, 2023 23:25 Buyela kuluhlu

I-GS-441524 licandelo lebhayoloji elisebenzayo le-Remdesivir



Intshayelelo

I-GS-441524 licandelo lebhayoloji elisebenzayo le-Remdesivir kwaye ibisetyenziswa kakhulu kwihlabathi jikelele ukunyanga ngokukhuselekileyo nangempumelelo iikati ze-feline infectious peritonitis (FlP) ngaphezulu kweenyanga ezili-18. I-FIP sisifo esiqhelekileyo nesibulala kakhulu kwiikati.

Umsebenzi

I-GS-441524 yi-molecule encinci enegama lesayensi le-nucleoside triphosphate competitive inhibitor, ebonisa umsebenzi onamandla we-antiviral ngokuchasene neentsholongwane ezininzi ze-RNA. Isebenza njengenye i-substrate kunye ne-RNA chain terminator ye-RNA exhomekeke kwi-RNA polymerase yentsholongwane. Uxinaniso olungenatyhefu lwe-GS-441524 kwiiseli ze-feline luphezulu njenge-100, oluthintela ngokufanelekileyo ukuphindaphinda kwe-FIPV kwinkcubeko yeseli ye-CRFK kunye ne-cat peritoneal macrophages enokosuleleka ngokwendalo.。 

Umbuzo: Yintoni i-GS?
A: I-GS imfutshane kwi-GS-441524 eyiyeza elichasene ne-viral (i-nucleoside analog) eliye laphilisa iikati nge-FIP kwiimvavanyo zentsimi ezenziwa kwi-UC Davis kodwa uDkt. Neils Pedersen kunye neqela lakhe. Jonga isifundo apha.
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Umbuzo: Lude kangakanani unyango?
A: Unyango olucetyiswayo olusekwe kulingo lwangaphambili lukaGqr. Pedersen luncinci kwiiveki ezili-12 zemihla ngemihla iinaliti ezingaphantsi kwesikhumba.
Umsebenzi wegazi kufuneka uhlolwe ekupheleni kweeveki ze-12 kwaye iimpawu zekati kufuneka zihlolwe ukubona ukuba unyango olongezelelweyo luyafuneka.

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