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  • GS-441524 jẹ paati lọwọ nipa biologically ti Remdesivir

Mar. Oṣu Karun Ọjọ 19, Ọdun 2023 23:25 Pada si akojọ

GS-441524 jẹ paati lọwọ nipa biologically ti Remdesivir



Ọrọ Iṣaaju

GS-441524 jẹ paati ti nṣiṣe lọwọ nipa biologically ti Remdesivir ati pe o ti lo jakejado agbaye lati lailewu ati imunadoko ni imularada awọn ologbo ti peritonitis àkóràn feline (FlP) fun oṣu mejidinlogun. FIP jẹ arun ti o wọpọ ati apaniyan pupọ ti awọn ologbo.

Išẹ

GS-441524 jẹ moleku kekere kan pẹlu orukọ imọ-jinlẹ ti nucleoside triphosphate inhibitor ifigagbaga, eyiti o ṣe afihan iṣẹ ṣiṣe antiviral ti o lagbara lodi si ọpọlọpọ awọn ọlọjẹ RNA. O ṣe iranṣẹ bi sobusitireti yiyan ati ipari RNA pq fun RNA polymerase ti o gbẹkẹle RNA gbogun ti. Idojukọ ti kii ṣe majele ti GS-441524 ninu awọn sẹẹli feline jẹ giga bi 100, eyiti o ṣe idiwọ ilodisi FIPV ni imunadoko ni aṣa sẹẹli CRFK ati awọn macrophages ologbo peritoneal nipa ti ara pẹlu ifọkansi kan。 

Q: Kini GS?
A: GS jẹ kukuru fun GS-441524 eyiti o jẹ oogun egboogi-gbogun ti esiperimenta (analogue nucleoside) ti o ni arowoto awọn ologbo pẹlu FIP ni awọn idanwo aaye ti a ṣe ni UC Davis ṣugbọn Dokita Neils Pedersen ati ẹgbẹ rẹ. Wo iwadi nibi.
O wa lọwọlọwọ bi abẹrẹ tabi oogun ẹnu botilẹjẹpe ẹya ẹnu ko tun wa ni ibigbogbo sibẹsibẹ. Jọwọ beere lọwọ abojuto kan!
Q: Bawo ni itọju naa ṣe pẹ to?
A: Itọju ti a ṣe iṣeduro ti o da lori idanwo aaye atilẹba ti Dokita Pedersen jẹ o kere ju ọsẹ 12 ti awọn abẹrẹ abẹ-awọ ojoojumọ.
O yẹ ki o ṣayẹwo iṣẹ ẹjẹ ni opin ọsẹ 12 ati pe o yẹ ki o ṣe ayẹwo awọn aami aisan ologbo lati rii boya o nilo itọju afikun.

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