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  • GS-441524 ke karolo e sebetsang ea bioloji ea Remdesivir

Mar. 19, 2023 23:25 Khutlela lethathamong

GS-441524 ke karolo e sebetsang ea bioloji ea Remdesivir



Selelekela

GS-441524 ke motsoako o sebetsang oa bioloji oa Remdesivir mme esale e sebelisoa lefatšeng ka bophara ho phekola ka mokhoa o sireletsehileng le ka katleho likatse tsa feline infectious peritonitis (FlP) ka nako e fetang likhoeli tse 18. FIP ke lefu le tloaelehileng le le bolaeang haholo la likatse.

Mosebetsi

GS-441524 ke molek'hule e nyane e nang le lebitso la saense la nucleoside triphosphate competitive inhibitor, e bonts'ang ts'ebetso e matla ea antiviral khahlano le livaerase tse ngata tsa RNA. E sebetsa e le karolo e 'ngoe ea substrate le terminator ea RNA bakeng sa RNA polymerase e itšetlehileng ka vaerase. Motsoako o senang chefo oa GS-441524 liseleng tsa nama e phahame ho feta 100, e thibelang phetiso ea FIPV ka mokhoa o atlehileng moetlong oa lisele tsa CRFK le li-macrophages tsa cat peritoneal tse tšoaelitsoeng ka tlhaho tse nang le mahloriso.。 

P: GS ke eng?
A: GS e khutšoanyane bakeng sa GS-441524 e leng lithethefatsi tse thibelang kokoana-hloko ea liteko (nucleoside analog) e phekotseng likatse tse nang le FIP litekong tsa masimo tse entsoeng UC Davis empa Dr. Neils Pedersen le sehlopha sa hae. Sheba thuto mona.
Hajoale e fumaneha e le ente kapa moriana o nooang le hoja mofuta oa molomo o ntse o e-so fumanehe ka bongata. Ke kopa o botse admin!
P: Kalafo e nka nako e kae?
K: Kalafo e khothaletsoang e ipapisitseng le teko ea mantlha ea Dr. Pedersen ke bonyane libeke tse 12 tsa liente tsa letsatsi le letsatsi tsa sub-cutaneous.
Ts'ebetso ea mali e lokela ho hlahlojoa qetellong ea libeke tse 12 mme matšoao a katse a lokela ho hlahlojoa ho bona hore na ho hlokahala kalafo e eketsehileng.

Arolelana
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