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  • I-GS-441524 iyingxenye ye-biologically esebenzayo ye-Remdesivir

Mar. 19, 2023 23:25 Buyela ohlwini

I-GS-441524 iyingxenye ye-biologically esebenzayo ye-Remdesivir



Isingeniso

I-GS-441524 iyingxenye ye-biologically esebenzayo ye-Remdesivir futhi ibisetshenziswa kabanzi emhlabeni jikelele ukwelapha ngokuphepha nangempumelelo amakati e-feline infectious peritonitis (FlP) ngaphezu kwezinyanga eziyi-18. I-FIP yisifo esivamile nesibulala kakhulu samakati.

Umsebenzi

I-GS-441524 i-molecule encane enegama lesayensi le-nucleoside triphosphate competitive inhibitor, ebonisa umsebenzi onamandla wokulwa namagciwane ngokumelene namagciwane amaningi e-RNA. Isebenza njengenye indawo engaphansi kanye ne-RNA chain terminator ye-RNA polymerase encike ku-RNA ngegciwane. Ukuhlushwa okungenabo ubuthi kwe-GS-441524 kumaseli we-feline kuphezulu njengokungu-100, okuvimbela ngempumelelo ukuphindaphinda kwe-FIPV kusiko lweseli ye-CRFK kanye nama-macrophages ekati e-peritoneal angenwe ngokwemvelo ngokugxila.。 

Umbuzo: Iyini i-GS?
A: I-GS ifushane ku-GS-441524 okuyisidakamizwa esilwa negciwane lesandulela ngculazi (i-nucleoside analog) eyelapha amakati nge-FIP ezivivinyweni zasenkambu ezenziwa e-UC Davis kodwa uDkt. Neils Pedersen nethimba lakhe. Bheka isifundo lapha.
Okwamanje itholakala njengomjovo noma umuthi ophuzwayo nakuba inguqulo yomlomo ingakatholakali kabanzi okwamanje. Ngicela ukubuza admin!
Umbuzo: Kuthatha isikhathi esingakanani ukwelashwa?
A: Ukwelashwa okunconyiwe okusekelwe ocwaningweni lwangempela lukaDkt. Pedersen ubuncane bamaviki angu-12 omjovo wansuku zonke we-sub-cutaneous.
Umsebenzi wegazi kufanele uhlolwe ekupheleni kwamasonto ayi-12 futhi izimpawu zekati kufanele zihlolwe ukuze kubonakale ukuthi kuyadingeka yini ukwelashwa okwengeziwe.

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