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Mar. 19, 2023 23:25 Hoʻi i ka papa inoa

ʻO GS-441524 ka mea hana olaola o Remdesivir



Hoʻolauna

ʻO GS-441524 ka mea olaola o Remdesivir a ua hoʻohana nui ʻia a puni ka honua no ka mālama pono ʻana i nā pōpoki o ka feline infectious peritonitis (FlP) no 18 mau mahina. He maʻi maʻamau a make loa ka FIP o nā pōpoki.

Hana

ʻO GS-441524 kahi mole liʻiliʻi me ka inoa ʻepekema o ka nucleoside triphosphate hoʻokūkū hoʻokūkū, e hōʻike ana i ka hana antiviral ikaika e kūʻē i nā maʻi RNA he nui. Hoʻohana ia ma ke ʻano he substrate ʻē aʻe a me ka mea hoʻopau kaulahao RNA no ka RNA polymerase hilinaʻi RNA viral. ʻO ke kiʻekiʻe o ka GS-441524 ʻaʻohe mea ʻawaʻawa i loko o nā pūpū feline e like me ka 100, ka mea e pale pono ai i ka hoʻopiʻi FIPV i ka moʻomeheu cell CRFK a me nā macrophages peritoneal pōpoki maʻi kūlohelohe me ka ʻike.。 

Nīnau: He aha ka GS?
A: He pōkole ʻo GS no GS-441524 he lāʻau anti-viral hoʻokolohua (nucleoside analog) i hoʻōla i nā pōpoki me FIP i nā hoʻokolohua kahua i mālama ʻia ma UC Davis akā ʻo Kauka Neils Pedersen a me kāna hui. E ʻike i ka haʻawina ma ʻaneʻi.
Loaʻa ia i kēia manawa ma ke ʻano he injection a i ʻole he lāʻau lapaʻau waha ʻoiai ʻaʻole i loaʻa ākea ka mana o ka waha. E ʻoluʻolu e nīnau i kahi admin!
Q: Pehea ka lōʻihi o ka mālama ʻana?
A: ʻO ka lāʻau lapaʻau i manaʻo ʻia e pili ana i ka hoʻāʻo mua ʻana o Kauka Pedersen he 12 pule ka liʻiliʻi o kēlā me kēia lā.
Pono e nānā ʻia ka hana koko ma ka pau ʻana o nā pule he 12 a e nānā ʻia nā hōʻailona o ka pōpoki e ʻike inā pono ka mālama ʻana.

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