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  • GS-441524 is the biologically active component of Remdesivir

Mar . 19, 2023 23:25 Back to list

GS-441524 is the biologically active component of Remdesivir



Introduction

GS-441524 is the biologically active component of Remdesivir and has been widely used around the world to safely and effectively cure cats of feline infectious peritonitis (FlP) for over 18 months. FIP is a common and highly fatal disease of cats.

Function

GS-441524 is a small molecule with a scientific name of nucleoside triphosphate competitive inhibitor, which shows strong antiviral activity against many RNA viruses. It serves as an alternative substrate and RNA chain terminator for viral RNA-dependent RNA polymerase. The non-toxic concentration of GS-441524 in feline cells is as high as 100, which effectively inhibits FIPV replication in CRFK cell culture and naturally infected cat peritoneal macrophages with a concentration 

Q: What is GS?
A: GS is short for GS-441524 which is an experimental anti-viral drug (nucleoside analog) that has cured cats with FIP in field trials conducted at UC Davis but Dr. Neils Pedersen and his team. See study here.
It is currently available as an injection or an oral medication although the oral version is still not widely available yet. Please ask an admin!
Q: How long is the treatment?
A: Recommended treatment based on Dr. Pedersen’s original field trial is a minimum of 12 weeks of daily sub-cutaneous injections.
Bloodwork should be checked at the end of 12 weeks and cat’s symptoms should be assessed to see if additional treatment is needed.

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