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Mar. 19, 2023 23:25 Bwererani ku mndandanda

GS-441524 ndiye gawo lachilengedwe la Remdesivir



Mawu Oyamba

GS-441524 ndi gawo lachilengedwe la Remdesivir ndipo lakhala likugwiritsidwa ntchito padziko lonse lapansi kuchiza amphaka a feline infectious peritonitis (FlP) kwa miyezi yopitilira 18. FIP ndi matenda ofala komanso oopsa kwambiri amphaka.

Ntchito

GS-441524 ndi kamolekyu kakang'ono kamene kamakhala ndi dzina lasayansi la nucleoside triphosphate competitive inhibitor, yomwe imawonetsa mphamvu zolimbana ndi ma virus ambiri a RNA. Imagwira ngati gawo laling'ono komanso choyimira cha RNA cha ma virus omwe amadalira RNA polymerase. Kuchuluka kwa GS-441524 m'maselo amphaka ndi okwera kwambiri mpaka 100, komwe kumalepheretsa kubwereza kwa FIPV mu CRFK cell cell komanso macrophages amphaka amphaka omwe ali ndi kachilombo koyambitsa matenda.。 

Q: Kodi GS ndi chiyani?
A: GS ndi yochepa kwa GS-441524 yomwe ndi mankhwala oyesera oletsa tizilombo toyambitsa matenda (nucleoside analog) omwe adachiritsa amphaka ndi FIP m'mayesero a m'munda omwe amachitidwa ku UC Davis koma Dr. Neils Pedersen ndi gulu lake. Onani phunziro apa.
Pakali pano ikupezeka ngati jekeseni kapena mankhwala apakamwa ngakhale kuti oral version sichinapezekebe. Chonde funsani admin!
Q: Kodi mankhwalawa ndi otalika bwanji?
A: Chithandizo chovomerezeka chochokera ku mayesero oyambirira a Dr. Pedersen ndi osachepera masabata a 12 a jakisoni wa subcutaneous tsiku lililonse.
Magazi amayenera kuyang'aniridwa kumapeto kwa masabata 12 ndipo zizindikiro za mphaka ziyenera kuyesedwa kuti muwone ngati pakufunika chithandizo china.

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