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Mar . 19, 2023 23:25 Ku laabo liiska

GS-441524 waa qaybta firfircoonida nafleyda ee Remdesivir



Hordhac

GS-441524 waa qaybta firfircoon ee bayooloji ee Remdesivir waxaana si weyn looga isticmaali jiray adduunka oo dhan si ammaan ah oo waxtar leh loogu daweeyo bisadaha peritonitis-ka feline infekshanka (FlP) in ka badan 18 bilood. FIP waa cudur caadi ah oo aad u dilaa ah bisadaha.

Shaqada

GS-441524 waa unug yar oo leh magac saynis ah oo ah nucleoside triphosphate inhibitor, kaas oo muujinaya firfircoonida fayraska ka hortagga fayraska badan ee RNA. Waxay u adeegtaa sidii substrate beddelka ah iyo joojinta silsiladda RNA ee fayraska RNA-ku-tiirsanaanta RNA polymerase. Isku-darka aan sunta ahayn ee GS-441524 ee unugyada feline-ka ayaa ah mid aad u sarreeya 100, taas oo si wax ku ool ah u joojinaysa ku-noqoshada FIPV ee dhaqanka unugyada CRFK iyo macrophages bisadaha dabiiciga ah ee cudurka qaba oo leh feejignaan.。 

S: Waa maxay GS?
J: GS waxay u soo gaabisay GS-441524 taas oo ah daawada tijaabada ah ee ka hortagga fayraska (nucleoside analogue) kaas oo daaweeyay bisadaha leh FIP ee tijaabooyinka goobta lagu sameeyay UC Davis laakiin Dr. Neils Pedersen iyo kooxdiisa. Halkan ka eeg daraasadda.
Hadda waxa loo heli karaa irbad ahaan ama dawo afka laga qaato in kasta oo nooca afka laga qaato aan weli si ballaadhan loo helin. Fadlan weydii admin!
S: Ilaa intee ayay daawadu jirtaa?
J: Daawaynta lagu taliyay ee ku salaysan tijaabadii asalka ahayd ee Dr. Pedersen waa ugu yaraan 12 toddobaad oo irbado maqaarka hoostiisa ah oo maalinle ah.
Shaqada dhiiga waa in la hubiyaa dhamaadka 12ka usbuuca waana in la qiimeeyaa calamadaha bisadaha si loo eego hadii loo baahan yahay daaweyn dheeraad ah.

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