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Mar. Ọktoba 19, 2023 23:25 Laghachi na ndepụta

GS-441524 bụ akụrụngwa Remdesivir na-arụ ọrụ na ndu



Okwu mmalite

GS-441524 bụ akụrụngwa Remdesivir na-arụ ọrụ n'ụzọ ndụ yana ejiri ya n'ọtụtụ ebe gburugburu ụwa iji gwọọ nwamba nke peritonitis na-efe efe (FlP) n'enweghị nsogbu ọ bụla karịa ọnwa 18. FIP bụ ọrịa a na-ahụkarị ma na-egbu egbu nke nwamba.

Ọrụ

GS-441524 bụ obere molekul nwere aha sayensị nke nucleoside triphosphate competitive inhibitor, nke na-egosi ọrụ mgbochi siri ike megide ọtụtụ nje RNA. Ọ na-eje ozi dị ka ihe ọzọ mkpụrụ na RNA yinye terminator maka viral RNA dabere RNA polymerase. Ntinye uche na-adịghị egbu egbu nke GS-441524 na mkpụrụ ndụ feline dị elu dị ka 100, nke na-egbochi mmegharị FIPV nke ọma na omenala CRFK cell na ọrịa na-ebute ọrịa peritoneal macrophages nke anụ ahụ na ntinye uche.。 

Ajụjụ: Gịnị bụ GS?
A: GS dị mkpụmkpụ maka GS-441524 nke bụ ihe nyocha nke ọgwụ nje (nucleoside analog) nke gwọọ nwamba nwere FIP na ule ubi a na-eme na UC Davis mana Dr. Neils Pedersen na ndị otu ya. Lee ọmụmụ ebe a.
Ọ dị ugbu a dị ka ịgba ntụtụ ma ọ bụ ọgwụ ọnụ ọ bụ ezie na ụdị ọnụ ka adịbeghị ebe niile. Biko jụọ onye nchịkwa!
Ajụjụ: Ogologo oge ole ka ọgwụgwọ ahụ dị?
A: Ngwọta akwadoro dabere na nnwale ubi izizi nke Dr. Pedersen bụ opekempe nke izu iri na abụọ nke injections subcutaneous kwa ụbọchị.
Ekwesịrị ịlele ọrụ ọbara na njedebe nke izu iri na abụọ na a ga-enyocha akara ngosi nwamba iji hụ ma ọ dị mkpa ọgwụgwọ ọzọ.

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