Product Description

Semaglutide (CAS No. 910463-68-2) is a groundbreaking GLP-1 receptor agonist designed to improve glycemic control in adults with type 2 diabetes. This synthetic peptide mimics the action of the natural hormone glucagon-like peptide-1 (GLP-1), which plays a critical role in regulating blood sugar levels. Semaglutide's unique chemical structure, featuring two key modifications—substitution of Gly with 2-aminoisobutyric acid (Aib) and the attachment of an 18-carbon fatty acid moiety—enhances its stability and efficacy. These modifications increase resistance to DPP-4 degradation and improve binding affinity to serum albumin, resulting in a prolonged half-life of approximately seven days in humans (NIST). Beyond diabetes management, Semaglutide has shown promise in aiding weight loss, making it a versatile therapeutic option.

Product Overview

Semaglutide is a high-purity (≥98%) solid powder with a molecular formula of C₁₈₇H₂₉₁N₄₅O₅₉ and a formula weight of 4113.57754 g/mol. Its chemical structure is engineered to maximize therapeutic benefits while ensuring stability under storage conditions. The product is available in powder form, requiring dissolution in dimethyl sulfoxide (DMSO) for use. Semaglutide is shipped under ambient temperatures as a non-hazardous chemical, maintaining stability during transit and customs clearance.

Technical Specifications

Parameter	Details
CAS No.	910463-68-2
Product Name	Semaglutide
Synonyms	Sermaglutide; Semaglutide fandachem; Semaglutide impurity; Sermaglutide USP/EP/BP; semaglutide; Sermaglutide CAS 910463 68 2
Molecular Formula	C187H291N45O59
Formula Weight	4113.57754 g/mol
Appearance	White to off-white solid powder
Purity	≥98%
Storage	Dry, dark, and at 0–4°C (short-term) or -20°C (long-term)
Solubility	Soluble in DMSO
Shipping Condition	Ambient temperature; non-hazardous chemical

Key Features and Advantages

Semaglutide's advanced design offers several critical advantages:

• Enhanced Stability: The structural modifications (Aib substitution and fatty acid attachment) increase resistance to enzymatic degradation, extending its half-life.
• High Efficacy: Clinical trials demonstrate significant improvements in glycemic control and weight loss, with a once-weekly dosing regimen for convenience.
• Flexibility: Available as a powder for custom formulation, allowing researchers and pharmaceutical companies to tailor solutions to specific needs.
• Regulatory Compliance: Adheres to stringent quality standards, ensuring safety and consistency for both research and commercial applications.

Applications

Semaglutide's versatility makes it suitable for a range of applications:

• Diabetes Management: Approved by the FDA for treating type 2 diabetes, Semaglutide improves insulin secretion and reduces glucagon release.
• Weight Loss: Clinical studies highlight its effectiveness in reducing body weight, making it a valuable tool for obesity treatment.
• Neurodegenerative Research: Emerging research suggests potential applications in Alzheimer's disease, though further studies are needed.
• Pharmaceutical Development: Serves as a critical intermediate in the production of GLP-1-based therapies, supporting innovation in endocrinology and metabolic disorders.

Company Background

Hebei Weimiao Import and Export Trade Co., Ltd. is a leading supplier of high-quality pharmaceutical intermediates, including Semaglutide. With a commitment to excellence, the company ensures rigorous quality control and compliance with international standards. Their expertise in pharmaceutical research and development positions them as a trusted partner for clients worldwide.

Why Choose Hebei Weimiao?

Hebei Weimiao stands out due to its comprehensive advantages:

• Manufacturer Direct: As a manufacturer, they offer competitive pricing and direct access to high-quality products.
• Sample Availability: Free samples are provided for evaluation, ensuring product suitability before bulk orders.
• Flexible Payment Options: Supports Western Union, T/T, BTC, Alibaba, and other secure payment methods.
• Quality Assurance: All products undergo 100% testing before delivery, with third-party verification available.
• Global Shipping: Efficient logistics ensure safe and timely delivery, with customs clearance handled by specialized shipping partners.

Frequently Asked Questions (FAQ)

Q: Are you a trading company or manufacturer?
A: We are a manufacturer, ensuring direct control over product quality and supply chain efficiency.

Q: Do you provide samples?
A: Yes, samples are available for evaluation before bulk production.

Q: What are your payment terms?
A: We accept Western Union, T/T, BTC, Alibaba, and other secure payment methods.

Q: Do you test all goods before delivery?
A: Yes, all products are 100% tested, with third-party testing available upon request.

Q: What is your delivery time?
A: Delivery begins after receipt of full payment, ensuring transparency and reliability.

Q: What is the minimum order quantity (MOQ)?
A: Any amount is acceptable, catering to both small-scale research and large-scale production needs.

Conclusion

Semaglutide represents a significant advancement in the treatment of type 2 diabetes and obesity, offering a unique combination of efficacy, stability, and versatility. Its development aligns with the rigorous standards upheld by organizations like the National Institute of Standards and Technology (NIST), which plays a pivotal role in establishing measurement standards for pharmaceuticals and medical devices. By leveraging cutting-edge research and quality control, Hebei Weimiao Import and Export Trade Co., Ltd. ensures that Semaglutide meets the highest industry benchmarks. For researchers, healthcare professionals, and pharmaceutical companies, Semaglutide provides a reliable solution for advancing therapeutic innovation.

References

1. National Institute of Standards and Technology (NIST). Retrieved from https://www.nist.gov/

2. Lau, J., Bloch, M., et al. (2015). "Structural Modifications of Semaglutide Enhance GLP-1 Receptor Agonist Activity." Journal of Medicinal Chemistry.

Product and Company Links

• Product Page
• Company Website
• NIST Standards
• Pharmaceutical Intermediates