With the increasing demand of customers, we also began to spend a lot of time and energy to invest in the research and development of this new powder pmk product, the purity is greatly improved. Storage is more convenient, and buyers are welcome to place large orders.

To a solution of piperonal (1, 3.00 g, 19.9 mmol) in CH2Cl2 (100 mL) was added (carbethoxyethylidene)triphenylphosphorane (2,14.5 g, 40.0 mmol), and the reaction mixture was stirred for 24 h at room temperature. The mixture was then concentrated at reduced pressure, and the residue was purified by flash column chromatography on silica gel (hexanes/EtOAc,10:1) to afford olefin 3 (4.45 g, 95%) as a colorless oil: 1H NMR (400 MHz, CDCl3) d 7.58 (s, 1H), 6.92 (d, J = 1.7 Hz, 1H), 6.90 (dd, J = 7.9, 1.7 Hz, 1H), 6.82 (d, J = 8.0 Hz, 1H), 5.97 (s, 2H), 4.24 (q, J = 7.1 Hz, 2H), 2.10 (d, J = 1.6 Hz, 3H),1.33 (t, J = 7.1 Hz, 3H); 13C NMR (100 MHz, CDCl3) d 168.7,147.6, 138.3, 129.9, 126.9, 124.6, 109.5, 108.2, 101.2, 60.7, 14.3,1 4.0; IR (ATR, cm-1): 2981, 2902,1698, 1628, 1502, 1489,1442, 1258, 1224; HRMS (EI) m/z calcd for C13H14O4 (M+) 234.0892, found 234.0895 [1].

PMK ethyl glycidate, also known as 2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester, is a white solid at room temperature and pressure. It is commonly used as an organic synthesis intermediate and pharmaceutical intermediate, particularly in the synthesis and derivatization of drug molecules and bioactive molecules. With its epoxy unit, this compound can react with a range of nucleophilic reagents to prepare corresponding methyl piperonyl derivatives.

Having regard to the Treaty on the Functioning of the European Union,Having regard to Regulation (EC) No 273/2004 of the European Parliament and of the Council of 11 February 2004 on drug precursors (1), and in particular Article 15 thereof,Having regard to Council Regulation (EC) No 111/2005 of 22 December 2004 laying down rules for the monitoring of trade between the Union and third countries in drug precursors (2), and in particular Article 30a thereof,

Although mercury’s mystique held the promise of power, many of the ancients also knew it to be toxic. It was in the mining of the element where mercury first became associated with human illness beginning as tremors and progressing to severe mental derangement. The largest natural source of mercury is cinnabar, its only known ore, and the richest deposits are found in Spain and Italy. This reddish mineral containing mercury and sulfur has been used as a pigment since prehistoric times. Cinnabar dating from 500 BC has been identified at a Mayan site in Guatemala, and prehistoric skulls painted with cinnabar have been found in Italy.The Romans used their mercury mines as penal institutions for criminals, slaves, and other undesirables. The warders were among the first to recognize that there was a high likelihood that the prisoners would become poisoned and spare the keepers the need for formal executions. Mercury is primarily a neurological poison, causing tremors, extreme mood changes, and eventually loss of hearing and restricted vision. Certain forms of mercury poisoning also cause damage to the liver and kidneys. The life span of a worker in those mines was tragically brief.

In the 1980s Chinese researchers found that the soil in the burial mound above the tomb contains mercury concentrations way above those elsewhere in the vicinity. Now some archaeologists working on the site believe that the body of the First Emperor may indeed lie amidst vast puddles of the liquid metal.  Yet it seems unlikely that anyone will gaze on such a sight in the foreseeable future. ‘We have no current plan to open the chambers,’ explains archaeologist Qingbo Duan of Northwest University in Xi’an, who led the mausoleum excavations from 1998 to 2008. ‘We have no mature technologies and effective measures to protect the relics,’ he says. So can we ever know the truth about Qin Shi Huangdi’s rivers of mercury? 

Mercury – named after a Roman god known for speed and agility – is a chemical element that has fascinated humans for thousands of years. Mercury is the only metallic element that is liquid under standard conditions. It flows easily and has very high surface tension, so it forms shiny rounded beads. When compared with most other metal elements, which are usually bits of greyish solids that tarnish quickly, it’s easy to see why mercury was thought to have special properties.

The legendary First Emperor of unified China, Qin Shi Huang, began his reign at just 13 years old. Despite his youth, he began seriously preparing for his death by ordering the construction of a magnificent mausoleum measuring 6.3 square kilometres. It took approximately 38 years to complete, with an insane workforce of 700,000 prisoners, slaves, and other social outcasts.He wished to build a microcosm of his entire legacy on earth to take with him into the afterlife. This included 8,000 terracotta soldiers (horses and all), a palace, a pyramid, and a burial mound containing his tomb. This tomb has never been opened for several reasons. First, the air might damage whatever may lie inside. Second, it may contain toxic levels of mercury. 

Mer­cury is a heavy, sil­very and very tox­ic met­al. One of the most well-known fea­tures of mer­cury is that in nor­mal con­di­tions this met­al is liq­uid and only freezes at –38.8°C! In na­ture there are only two el­e­ments that are liq­uid in nor­mal con­di­tions – mer­cury and bromine.In the earth’s crust, mer­cury is a very rare el­e­ment, but rocks in which mer­cury is found usu­al­ly con­tain it in rather high con­cen­tra­tions. This is be­cause mer­cury mix­es poor­ly with el­e­ments that make up most of the earth’s crust, and so “ac­cu­mu­la­tions” of min­er­als con­tain­ing mer­cury are formed. The most abun­dant of them are cinnabar (mer­cury sul­fide HgS) and corderoit (Hg₃S₂­Cl₂).

The mercury market size is projected to increase by USD 695.42 million, at a CAGR of 2.94% between 2023 and 2028. The market report includes a comprehensive outlook on the market offering forecasts for the industry segmented by Application, which comprises electrical and electronics, measuring and controlling devices, dental application and gold processing. Additionally, it categorizes Product into metal, alloys and compounds and covers Region, including North America, APAC, Europe, Middle East and Africa, and South America. The report provides market size, historical data spanning from 2018 to 2022, and future projections, all presented in terms of value in USD million for each of the mentioned segments.The growth of the market is propelled by the increase in the adoption of mercury in button cell batteries, although its progress is hindered by the stringent regulation on the emission and use of mercury. Furthermore, there is a notable upward trend in the increasing efforts to recycle and recover emissions of mercury. 

An online dump of classified Chinese documents from a private security contractor is shining a light on hacking efforts the country's spy agency uses on both foreigners and Chinese citizens. The leaked documents show how Chinese authorities deploy these tools to surveil dissidents overseas, hack other nations, and promote pro-Beijing narratives on social media. A menu of services revealed that $15,000 granted a local government in southwest China access to a traffic police website in Vietnam.Disinformation campaigns and account hacking on X cost $100,000 - and $278,000 got customers personal information from social media accounts like Telegram and Facebook.Meanwhile, Chinese police are investigating the hack of the security contractor, which is linked to the nation's top policing agency and other parts of its government.

PMK ethyl glycidate as an intermediate in the synthesis of desoxy phenethylamine analogs. The desoxy phenethylamine analogs in this study represent a combination of alkyl side-chain and cyclic amines (azetidine, pyrrolidine, piperidine and azepane) to yield a set of mols. of identical elemental compn. as well as major mass spectral fragment ions (base peaks) of identical elemental compn.  These desoxy phenethylamine analogs of the aminoketone designer drug, 3,4-methylenedioxy-pyrrovalerone (MDPV) related to the natural product cathinone were prepd. from piperonal (3,4-methylenedioxybenzaldehyde) via the intermediate precursor ketones.  The aminoketones and the desoxy phenethylamine regioisomers were each sepd. in capillary gas chromatog. expts. using an Rxi-7Sil MS stationary phase with the aminoketones showing greater retention than the corresponding desoxyamines

PMK ethyl glycidate, also known as 2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester, is a white solid at room temperature and pressure. It is commonly used as an organic synthesis intermediate and pharmaceutical intermediate, particularly in the synthesis and derivatization of drug molecules and bioactive molecules. With its epoxy unit, this compound can react with a range of nucleophilic reagents to prepare corresponding methyl piperonyl derivatives.

The Drug Enforcement Administration is proposing to designate 3,4-MDP-2-P methyl glycidate (PMK glycidate), including its optical and geometric isomers; 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid), including its salts, optical and geometric isomers, and salts of isomers; and alpha -phenylacetoacetamide (APAA), including its optical isomers, as list I chemicals under the Controlled Substances Act (CSA). PMK glycidate and PMK glycidic acid are used in and are important to the manufacture of the schedule I controlled substance 3,4-methylenedioxymethamphetamine (MDMA) and other “ecstasy”-type substances. APAA is used in and is important to the manufacture of the schedule II controlled substances amphetamine and methamphetamine. If finalized, this action would subject handlers (manufacturers, distributors, importers, and exporters) of PMK glycidate, PMK glycidic acid, and APAA to the chemical regulatory provisions of the CSA and its implementing regulations. This action does not propose the establishment of a threshold for domestic and international transactions of these chemicals. As such, all transactions involving any of these chemicals, regardless of size, would be regulated. In addition, this action proposes that chemical mixtures containing any of these three chemicals would not be exempt from regulatory requirements at any concentration. Therefore, all transactions of chemical mixtures containing any quantity of PMK glycidate, PMK glycidic acid, or APAA would be regulated.

Are pills stronger than ever, or just more dangerous? Does 'molly' actually contain any ecstasy? And what's a 'precursor'? This is what's happening with MDMA in 2015.It's 27 years since MDMA hit the front pages of British newspapers, and for a drug that's so widely consumed – only cannabis, alcohol and cocaine are more popular – it's still something of an enigma.In 2015, though, the story is not only mysterious, it's as complex as it is confusing and contradictory. As the MDMA market matures, it is splitting, with dirty, contaminated and downright deadly pills at one end of the scale, and dangerously high-dose tablets and unprecedentedly pure crystals at the other. Both these scenarios can pose risks and (let's be honest) offer enormous pleasure to users. In this feature, we've asked experts in the fields of chemistry, medicine, and clubbing to help you navigate the ever-changing landscape of ecstasy in 2015.

Shipping is the most important for bulk chemicals，We have the more than 10 years perfessional shipping agent, 100% pass delivery to USA, Canada, Spain, Germany, Netherlands, Poland, UKFor bulk more than 100kg, we main use special line,such as DHL,UPS, Purolator, Canada Post, GLS, DPD…..We will use normal name to make all import documents and relable on the packing such as engine oil, glue, paint to distinguish it to keep the buyer received safe.

PMK Glycidate is a chemical substance that is used in the production of various items such as fragrances, dyes, plastics, and pharmaceuticals. It is a valuable component in the creation of high-quality perfumes and colognes as it gives them a unique and long-lasting scent.In the pharmaceutical industry, PMK Glycidate is used to create drugs that can treat a wide range of medical conditions. It is also used to make pain-relief medication and anti-inflammatory drugs.Furthermore, PMK Glycidate is used in research and development of new chemicals. It has unique chemical properties which makes it very useful for the creation of new substances with improved characteristics.Overall, the use of PMK Glycidate has significantly improved the quality of products in different industries. Its versatile applications have made it an essential component in the production of various items, leading to better and more efficient production processes.

The APAA can manufacture the controlled substance amphetamine and is very important to its manufacture.Thus,It was finally determined that handlers (manufacturers, distributors, importers and exporters) of PMK Glycine.PMK Glycidyl Acid and APAA are in compliance with the chemical regulations of the CSA and its implementing regulations. Thus,there are no thresholds for domestic and international trade of these chemicals not mentioned.Thus,he authorities will regulate all transactions involving these chemicals, regardless of size. Chemical mixtures containing any of these three chemicals, regardless of concentration, are not exempt from regulatory requirements.

he Drug Enforcement Administration is proposing to designate 3,4-MDP-2-P methyl glycidate (PMK glycidate), including its optical and geometric isomers; 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid), including its salts, optical and geometric isomers, and salts of isomers; and alpha-phenylacetoacetamide (APAA), including its optical isomers, as list I chemicals under the Controlled Substances Act (CSA).

The Drug Enforcement Administration is finalizing a December 21, 2020, notice of proposed rulemaking to designate three chemicals, known as PMK glycidate, PMK glycidic acid, and APAA, as list I chemicals under the Controlled Substances Act (CSA).