Hebei Weimiao Biology Co., LTD 1
Location
  • Home
  • bromazolam with best price

Jan . 30, 2024 14:39 Back to list

PMK ethyl glycidate-What is the synthesis and application of PMK ethyl glycidate?



What is the synthesis and application of PMK ethyl glycidate?

 
DaisyAnswered Mar 06 2023

 

PMK ethyl glycidate, also known as 2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester, is a white solid at room temperature and pressure. It is commonly used as an organic synthesis intermediate and pharmaceutical intermediate, particularly in the synthesis and derivatization of drug molecules and bioactive molecules. With its epoxy unit, this compound can react with a range of nucleophilic reagents to prepare corresponding methyl piperonyl derivatives.

Image of PMK ethyl glycidate

Figure 1: Image of PMK ethyl glycidate

 

 

GS-441524 适用于 Cat FIPV

Synthesis Method

Synthesis route of PMK ethyl glycidate

Figure 2: Synthesis route of PMK ethyl glycidate

In a dry reaction flask, the precursor compound of PMK ethyl glycidate (2 mmol) is dissolved in dichloromethane (20 mL), and the resulting reaction solution is cooled to 0°C. Slowly add m-chloroperbenzoic acid (863 mg, 5 mmol) to the mixture, and the reaction mixture is stirred at room temperature for 15 hours. After the reaction, extract the mixture with dichloromethane three times, combine all the organic layers, wash the organic layer with 5% NaHCO3 solution and brine, dry the organic layer with anhydrous sodium sulfate, filter off the drying agent, and concentrate the filtrate under vacuum to obtain the target product molecule.[1]

Application

PMK ethyl glycidate can be used as an organic synthesis intermediate and pharmaceutical intermediate. The reducible unit in its structure can react with organic amines to obtain ring-opened amine products.

Application of PMK ethyl glycidate

Figure 3: Application of PMK ethyl glycidate

In a dry reactor, dissolve PMK ethyl glycidate in methanol, then add a tetrahydrofuran solution of methylamine to the reaction mixture. Heat the reaction mixture to reflux and stir for several hours. After the reaction, neutralize the reaction system with formic acid, then extract the mixture with ethyl acetate three times, combine all the organic layers, dry the organic layer with anhydrous sodium sulfate, filter off the drying agent, and concentrate the filtrate under vacuum. The residue is purified by silica gel column chromatography to obtain the target product molecule.[1]

 

Share
Next：

Latest news

If you are interested in our products, you can choose to leave your information here, and we will be in touch with you shortly.


Hit enter to search or ESC to close
en_USEnglish
afAfrikaans sqAlbanian amAmharic arArabic hyArmenian azAzerbaijani euBasque belBelarusian bn_BDBengali bs_BABosnian bg_BGBulgarian caCatalan cebCebuano zh_CNChina zh_TWChina (Taiwan) coCorsican hrCroatian cs_CZCzech da_DKDanish nl_NLDutch eoEsperanto etEstonian fiFinnish fr_FRFrench fyFrisian gl_ESGalician ka_GEGeorgian de_DEGerman elGreek guGujarati htHaitian Creole haHausa hawHawaiian he_ILHebrew hi_INHindi hmnMiao hu_HUHungarian is_ISIcelandic igIgbo id_IDIndonesian gaIrish it_ITItalian jaJapanese jvJavanese knKannada kkKazakh kmKhmer rwRwandese ko_KRKorean ckbKurdish kyKyrgyz loLao laLatin lvLatvian lt_LTLithuanian lbLuxembourgish mk_MKMacedonian mgMalgashi ms_MYMalay ml_INMalayalam mtMaltese miMaori mrMarathi mnMongolian my_MMMyanmar ne_NPNepali nb_NONorwegian nyNorwegian orOccitan psPashto fa_IRPersian pl_PLPolish pt_PTPortuguese pa_INPunjabi ro_RORomanian ru_RURussian smSamoan gdScottish Gaelic sr_RSSerbian stSesotho snShona sdSindhi si_LKSinhala sk_SKSlovak sl_SISlovenian soSomali es_ESSpanish suSundanese swSwahili sv_SESwedish tlTagalog tgTajik ta_INTamil tt_RUTatar teTelugu thThai tr_TRTurkish tkTurkmen ukUkrainian urUrdu ug_CNUighur uz_UZUzbek viVietnamese cyWelsh xhBantu yiYiddish yoYoruba zuZulu en_USEnglish