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To a solution of piperonal (1, 3.00 g, 19.9 mmol) in CH2Cl2 (100 mL) was added (carbethoxyethylidene)triphenylphosphorane (2,14.5 g, 40.0 mmol), and the reaction mixture was stirred for 24 h at room temperature. The mixture was then concentrated at reduced pressure, and the residue was purified by flash column chromatography on silica gel (hexanes/EtOAc,10:1) to afford olefin 3 (4.45 g, 95%) as a colorless oil: 1H NMR (400 MHz, CDCl3) d 7.58 (s, 1H), 6.92 (d, J = 1.7 Hz, 1H), 6.90 (dd, J = 7.9, 1.7 Hz, 1H), 6.82 (d, J = 8.0 Hz, 1H), 5.97 (s, 2H), 4.24 (q, J = 7.1 Hz, 2H), 2.10 (d, J = 1.6 Hz, 3H),1.33 (t, J = 7.1 Hz, 3H); 13C NMR (100 MHz, CDCl3) d 168.7,147.6, 138.3, 129.9, 126.9, 124.6, 109.5, 108.2, 101.2, 60.7, 14.3,1 4.0; IR (ATR, cm-1): 2981, 2902,1698, 1628, 1502, 1489,1442, 1258, 1224; HRMS (EI) m/z calcd for C13H14O4 (M+) 234.0892, found 234.0895 [1].

PMK ethyl glycidate, also known as 2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester, is a white solid at room temperature and pressure. It is commonly used as an organic synthesis intermediate and pharmaceutical intermediate, particularly in the synthesis and derivatization of drug molecules and bioactive molecules. With its epoxy unit, this compound can react with a range of nucleophilic reagents to prepare corresponding methyl piperonyl derivatives.

Having regard to the Treaty on the Functioning of the European Union,Having regard to Regulation (EC) No 273/2004 of the European Parliament and of the Council of 11 February 2004 on drug precursors (1), and in particular Article 15 thereof,Having regard to Council Regulation (EC) No 111/2005 of 22 December 2004 laying down rules for the monitoring of trade between the Union and third countries in drug precursors (2), and in particular Article 30a thereof,

PMK ethyl glycidate as an intermediate in the synthesis of desoxy phenethylamine analogs. The desoxy phenethylamine analogs in this study represent a combination of alkyl side-chain and cyclic amines (azetidine, pyrrolidine, piperidine and azepane) to yield a set of mols. of identical elemental compn. as well as major mass spectral fragment ions (base peaks) of identical elemental compn.  These desoxy phenethylamine analogs of the aminoketone designer drug, 3,4-methylenedioxy-pyrrovalerone (MDPV) related to the natural product cathinone were prepd. from piperonal (3,4-methylenedioxybenzaldehyde) via the intermediate precursor ketones.  The aminoketones and the desoxy phenethylamine regioisomers were each sepd. in capillary gas chromatog. expts. using an Rxi-7Sil MS stationary phase with the aminoketones showing greater retention than the corresponding desoxyamines

PMK ethyl glycidate, also known as 2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester, is a white solid at room temperature and pressure. It is commonly used as an organic synthesis intermediate and pharmaceutical intermediate, particularly in the synthesis and derivatization of drug molecules and bioactive molecules. With its epoxy unit, this compound can react with a range of nucleophilic reagents to prepare corresponding methyl piperonyl derivatives.

Are pills stronger than ever, or just more dangerous? Does 'molly' actually contain any ecstasy? And what's a 'precursor'? This is what's happening with MDMA in 2015.It's 27 years since MDMA hit the front pages of British newspapers, and for a drug that's so widely consumed – only cannabis, alcohol and cocaine are more popular – it's still something of an enigma.In 2015, though, the story is not only mysterious, it's as complex as it is confusing and contradictory. As the MDMA market matures, it is splitting, with dirty, contaminated and downright deadly pills at one end of the scale, and dangerously high-dose tablets and unprecedentedly pure crystals at the other. Both these scenarios can pose risks and (let's be honest) offer enormous pleasure to users. In this feature, we've asked experts in the fields of chemistry, medicine, and clubbing to help you navigate the ever-changing landscape of ecstasy in 2015.

Shipping is the most important for bulk chemicals，We have the more than 10 years perfessional shipping agent, 100% pass delivery to USA, Canada, Spain, Germany, Netherlands, Poland, UKFor bulk more than 100kg, we main use special line,such as DHL,UPS, Purolator, Canada Post, GLS, DPD…..We will use normal name to make all import documents and relable on the packing such as engine oil, glue, paint to distinguish it to keep the buyer received safe.

PMK Glycidate is a chemical substance that is used in the production of various items such as fragrances, dyes, plastics, and pharmaceuticals. It is a valuable component in the creation of high-quality perfumes and colognes as it gives them a unique and long-lasting scent.In the pharmaceutical industry, PMK Glycidate is used to create drugs that can treat a wide range of medical conditions. It is also used to make pain-relief medication and anti-inflammatory drugs.Furthermore, PMK Glycidate is used in research and development of new chemicals. It has unique chemical properties which makes it very useful for the creation of new substances with improved characteristics.Overall, the use of PMK Glycidate has significantly improved the quality of products in different industries. Its versatile applications have made it an essential component in the production of various items, leading to better and more efficient production processes.

The APAA can manufacture the controlled substance amphetamine and is very important to its manufacture.Thus,It was finally determined that handlers (manufacturers, distributors, importers and exporters) of PMK Glycine.PMK Glycidyl Acid and APAA are in compliance with the chemical regulations of the CSA and its implementing regulations. Thus,there are no thresholds for domestic and international trade of these chemicals not mentioned.Thus,he authorities will regulate all transactions involving these chemicals, regardless of size. Chemical mixtures containing any of these three chemicals, regardless of concentration, are not exempt from regulatory requirements.

he Drug Enforcement Administration is proposing to designate 3,4-MDP-2-P methyl glycidate (PMK glycidate), including its optical and geometric isomers; 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid), including its salts, optical and geometric isomers, and salts of isomers; and alpha-phenylacetoacetamide (APAA), including its optical isomers, as list I chemicals under the Controlled Substances Act (CSA).

The Drug Enforcement Administration is finalizing a December 21, 2020, notice of proposed rulemaking to designate three chemicals, known as PMK glycidate, PMK glycidic acid, and APAA, as list I chemicals under the Controlled Substances Act (CSA).

PMK ethyl glycidate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical chemical production process.

The Drug Enforcement Administration is finalizing a December 21, 2020, notice of proposed rulemaking to designate three chemicals, known as PMK glycidate, PMK glycidic acid, and APAA, as list I chemicals under the Controlled Substances Act (CSA).

The Drug Enforcement Administration is proposing to designate 3,4-MDP-2-P methyl glycidate (PMK glycidate), including its optical and geometric isomers; 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid), including its salts, optical and geometric isomers, and salts of isomers; and alpha-phenylacetoacetamide (APAA), including its optical isomers, as list I chemicals under the Controlled Substances Act (CSA).

For the reasons discussed above, the Acting Administrator of DEA finds that PMK glycidate, PMK glycidic acid, and APAA are used in the manufacture of a controlled substance in violation of the CSA, and are important to the manufacture of these controlled substances. Therefore, the Acting Administrator proposes the designation of PMK glycidate, PMK glycidic acid, and APAA as list I chemicals.

Pharmaceutical intermediates serve as a critical link between the discovery of new drug candidates and the commercial production of pharmaceutical products. They allow for the synthesis of complex molecules and provide the necessary chemical transformations to convert raw materials into active drugs.Pharmaceutical intermediates contribute to enhancing drug efficacy, stability, and bioavailability, thereby ensuring the quality and effectiveness of medications. These intermediates also play a vital role in achieving regulatory compliance by meeting the stringent standards set by regulatory authorities.

The Pharmaceutical Intermediates is moderately competitive with the presence of local as well as global companies.  Some of the key players which are contributing to the growth of the market include Aceto Corporation, BASF SE, Chiracon GmbH, Yin-sheng Biotech Co., Ltd., Dishman Group, Green Vision Life Sciences, Midas Pharma GmbH, Sanofi SA, Vertellus Holdings LLC., among others. The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the pharmaceutical intermediates market globally.    

According to Wisdom Research Consulting, pharmaceutical intermediates are single chemical substances with high purity obtained through chemical or biological reactions, similar to the production method of chemical raw materials. Therefore, China's chemical raw materials manufacturers usually produce pharmaceutical intermediates, and their level of development is closely related to the development of chemical raw materials and chemical drug preparations. In the future, the expiration of many patented drugs will lead to the availability of generic drugs. This will create a broad market space and provide good opportunities for development in the pharmaceutical intermediates industry.

Specific factors that are driving the market growth include the increasing prevalence of chronic diseases and growing R&D initiatives and activities in the pharmaceutical industry. Given that these pharma intermediates are used in the treatment of cancer detection and a variety of chronic diseases, the rise in the prevalence of chronic diseases is projected to propel market expansion in the area under study. For instance, chronic diseases account for around 41 million annual fatalities, or 71% of all fatalities worldwide, according to the WHO's key facts on non-communicable diseases published in April 2021. The high fatality rate from these diseases increases the demand for early intervention, which in turn propels the market's expansion.