Introduction to Semaglutide

Semaglutide, a groundbreaking compound with the CAS number 910463-68-2, has emerged as a pivotal player in the pharmaceutical industry. This synthetic peptide, chemically similar to the hormone glucagon-like peptide-1 (GLP-1), is designed to improve glycemic control in adults with type 2 diabetes (T2DM) and aid in weight loss for individuals with obesity. Its unique structure and mechanism of action set it apart from traditional GLP-1 receptor agonists, making it a subject of significant interest among researchers and healthcare professionals.

Product Overview

Semaglutide is a pharmaceutical intermediate that functions as a GLP-1 receptor agonist. It was approved by the U.S. Food and Drug Administration (FDA) in late 2017 as a once-weekly injection, offering a convenient and effective treatment option for patients. The compound's chemical structure incorporates two key modifications: the substitution of glycine with 2-aminoisobutyric acid (Aib) at position 2 and the attachment of an 18-carbon fatty acid to the side chain of Lys-26. These modifications enhance its resistance to dipeptidyl peptidase-4 (DPP-4) and increase its binding affinity to serum albumin, resulting in a half-life of approximately seven days in humans (NIST).

Key Applications

• Weight Loss: Semaglutide has demonstrated significant efficacy in promoting weight loss, making it a valuable tool in the management of obesity.
• Anti-Diabetic Therapy: It improves glycemic control by stimulating insulin secretion and reducing glucagon release.
• Alzheimer's Disease Research: Preliminary studies suggest potential neuroprotective effects, though further research is needed.

Technical Specifications

Parameter	Detalji
CAS broj	910463-68-2
Hemijski naziv	Semaglutide
Sinonimi	Sermaglutide, Semaglutide fandachem, Semaglutide impurity, etc.
Molecular Formula	C187H291N45O59
Formula Weight	4113.57754
Izgled	White to off-white solid powder
Čistoća	>98%
Skladištenje	Dry, dark, and at 0–4°C for short-term or -20°C for long-term
Rastvorljivost	Soluble in DMSO
Shipping Condition	Ambient temperature as non-hazardous chemical

Company Background: Hebei Weimiao Import and Export Trade Co., Ltd.

Hebei Weimiao Import and Export Trade Co., Ltd. is a leading manufacturer specializing in the production and supply of high-quality active pharmaceutical intermediates. With a commitment to innovation and excellence, the company has established itself as a trusted partner in the pharmaceutical industry. Their state-of-the-art facilities and rigorous quality control processes ensure that products meet the highest standards of purity and efficacy.

Why Choose Hebei Weimiao?

• Manufacturer Direct: As a direct manufacturer, Hebei Weimiao offers competitive pricing and personalized service.
• Sample Availability: Free samples are available for evaluation before bulk production, allowing clients to assess product quality.
• Flexible Payment Terms: The company accepts Western Union, T/T, BTC, Alibaba, and other payment methods.
• Quality Assurance: All products undergo 100% testing before delivery, with third-party testing options available.

Advantages and Features of Semaglutide

Semaglutide's unique properties make it a preferred choice for pharmaceutical applications. Its extended half-life reduces the frequency of administration, enhancing patient compliance. Additionally, its high binding affinity to serum albumin ensures sustained therapeutic effects. The compound's solubility in DMSO facilitates its use in various formulations, including injectable solutions.

Key Advantages

• Long-Lasting Effects: Once-weekly dosing improves convenience and adherence.
• High Purity: >98% purity ensures consistent therapeutic outcomes.
• Stable Storage: Proper storage conditions maintain product integrity over extended periods.

Applications in Healthcare and Research

Semaglutide's applications extend beyond diabetes management. Its potential in weight loss and neurodegenerative disease research highlights its versatility. For instance, studies have explored its role in Alzheimer's disease, where its neuroprotective properties could offer new therapeutic avenues. The compound's ability to modulate GLP-1 receptors also makes it a valuable tool in understanding metabolic disorders.

Industry Applications

• Pharmaceutical Industry: Used in the development of anti-diabetic and weight-loss medications.
• Research and Development: Valuable for studying GLP-1 receptor biology and drug delivery systems.
• Biotechnology: Applications in the production of biosimilars and biologics.

Conclusion

Semaglutide represents a significant advancement in the treatment of type 2 diabetes and obesity. Its innovative design, coupled with the expertise of manufacturers like Hebei Weimiao Import and Export Trade Co., Ltd., ensures that this compound meets the highest standards of quality and efficacy. As research continues to uncover new applications, Semaglutide is poised to play an even greater role in healthcare and pharmaceutical innovation.

Reference

National Institute of Standards and Technology (NIST) provides critical measurements and standards that underpin the development of pharmaceuticals and medical devices. Their work ensures the accuracy and reliability of scientific research, which is essential for the advancement of compounds like Semaglutide.

Additional Resources

• Product Page
• NIST Website

FAQ

Q: Are you a trading company or manufacturer?
A: We are a manufacturer.

Q: Do you provide samples?
A: Yes, samples are available for evaluation before bulk production.

Q: What payment terms do you accept?
A: Western Union, T/T, BTC, Alibaba, etc.

Q: Is third-party testing available?
A: Yes, our products are 100% tested before delivery, with third-party testing options available.

Q: What is the MOQ?
A: Any amount is acceptable.

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