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To a solution of piperonal (1, 3.00 g, 19.9 mmol) in CH2Cl2 (100 mL) was added (carbethoxyethylidene)triphenylphosphorane (2,14.5 g, 40.0 mmol), and the reaction mixture was stirred for 24 h at room temperature. The mixture was then concentrated at reduced pressure, and the residue was purified by flash column chromatography on silica gel (hexanes/EtOAc,10:1) to afford olefin 3 (4.45 g, 95%) as a colorless oil: 1H NMR (400 MHz, CDCl3) d 7.58 (s, 1H), 6.92 (d, J = 1.7 Hz, 1H), 6.90 (dd, J = 7.9, 1.7 Hz, 1H), 6.82 (d, J = 8.0 Hz, 1H), 5.97 (s, 2H), 4.24 (q, J = 7.1 Hz, 2H), 2.10 (d, J = 1.6 Hz, 3H),1.33 (t, J = 7.1 Hz, 3H); 13C NMR (100 MHz, CDCl3) d 168.7,147.6, 138.3, 129.9, 126.9, 124.6, 109.5, 108.2, 101.2, 60.7, 14.3,1 4.0; IR (ATR, cm-1): 2981, 2902,1698, 1628, 1502, 1489,1442, 1258, 1224; HRMS (EI) m/z calcd for C13H14O4 (M+) 234.0892, found 234.0895 [1].

PMK ethyl glycidate, also known as 2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester, is a white solid at room temperature and pressure. It is commonly used as an organic synthesis intermediate and pharmaceutical intermediate, particularly in the synthesis and derivatization of drug molecules and bioactive molecules. With its epoxy unit, this compound can react with a range of nucleophilic reagents to prepare corresponding methyl piperonyl derivatives.

Having regard to the Treaty on the Functioning of the European Union,Having regard to Regulation (EC) No 273/2004 of the European Parliament and of the Council of 11 February 2004 on drug precursors (1), and in particular Article 15 thereof,Having regard to Council Regulation (EC) No 111/2005 of 22 December 2004 laying down rules for the monitoring of trade between the Union and third countries in drug precursors (2), and in particular Article 30a thereof,

PMK ethyl glycidate as an intermediate in the synthesis of desoxy phenethylamine analogs. The desoxy phenethylamine analogs in this study represent a combination of alkyl side-chain and cyclic amines (azetidine, pyrrolidine, piperidine and azepane) to yield a set of mols. of identical elemental compn. as well as major mass spectral fragment ions (base peaks) of identical elemental compn.  These desoxy phenethylamine analogs of the aminoketone designer drug, 3,4-methylenedioxy-pyrrovalerone (MDPV) related to the natural product cathinone were prepd. from piperonal (3,4-methylenedioxybenzaldehyde) via the intermediate precursor ketones.  The aminoketones and the desoxy phenethylamine regioisomers were each sepd. in capillary gas chromatog. expts. using an Rxi-7Sil MS stationary phase with the aminoketones showing greater retention than the corresponding desoxyamines

PMK ethyl glycidate, also known as 2-Oxiranecarboxylicacid, 3-(1,3-benzodioxol-5-yl)-2-Methyl-, ethyl ester, is a white solid at room temperature and pressure. It is commonly used as an organic synthesis intermediate and pharmaceutical intermediate, particularly in the synthesis and derivatization of drug molecules and bioactive molecules. With its epoxy unit, this compound can react with a range of nucleophilic reagents to prepare corresponding methyl piperonyl derivatives.

The Drug Enforcement Administration is proposing to designate 3,4-MDP-2-P methyl glycidate (PMK glycidate), including its optical and geometric isomers; 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid), including its salts, optical and geometric isomers, and salts of isomers; and alpha -phenylacetoacetamide (APAA), including its optical isomers, as list I chemicals under the Controlled Substances Act (CSA). PMK glycidate and PMK glycidic acid are used in and are important to the manufacture of the schedule I controlled substance 3,4-methylenedioxymethamphetamine (MDMA) and other “ecstasy”-type substances. APAA is used in and is important to the manufacture of the schedule II controlled substances amphetamine and methamphetamine. If finalized, this action would subject handlers (manufacturers, distributors, importers, and exporters) of PMK glycidate, PMK glycidic acid, and APAA to the chemical regulatory provisions of the CSA and its implementing regulations. This action does not propose the establishment of a threshold for domestic and international transactions of these chemicals. As such, all transactions involving any of these chemicals, regardless of size, would be regulated. In addition, this action proposes that chemical mixtures containing any of these three chemicals would not be exempt from regulatory requirements at any concentration. Therefore, all transactions of chemical mixtures containing any quantity of PMK glycidate, PMK glycidic acid, or APAA would be regulated.

Are pills stronger than ever, or just more dangerous? Does 'molly' actually contain any ecstasy? And what's a 'precursor'? This is what's happening with MDMA in 2015.It's 27 years since MDMA hit the front pages of British newspapers, and for a drug that's so widely consumed – only cannabis, alcohol and cocaine are more popular – it's still something of an enigma.In 2015, though, the story is not only mysterious, it's as complex as it is confusing and contradictory. As the MDMA market matures, it is splitting, with dirty, contaminated and downright deadly pills at one end of the scale, and dangerously high-dose tablets and unprecedentedly pure crystals at the other. Both these scenarios can pose risks and (let's be honest) offer enormous pleasure to users. In this feature, we've asked experts in the fields of chemistry, medicine, and clubbing to help you navigate the ever-changing landscape of ecstasy in 2015.

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PMK Glycidate is a chemical substance that is used in the production of various items such as fragrances, dyes, plastics, and pharmaceuticals. It is a valuable component in the creation of high-quality perfumes and colognes as it gives them a unique and long-lasting scent.In the pharmaceutical industry, PMK Glycidate is used to create drugs that can treat a wide range of medical conditions. It is also used to make pain-relief medication and anti-inflammatory drugs.Furthermore, PMK Glycidate is used in research and development of new chemicals. It has unique chemical properties which makes it very useful for the creation of new substances with improved characteristics.Overall, the use of PMK Glycidate has significantly improved the quality of products in different industries. Its versatile applications have made it an essential component in the production of various items, leading to better and more efficient production processes.

The APAA can manufacture the controlled substance amphetamine and is very important to its manufacture.Thus,It was finally determined that handlers (manufacturers, distributors, importers and exporters) of PMK Glycine.PMK Glycidyl Acid and APAA are in compliance with the chemical regulations of the CSA and its implementing regulations. Thus,there are no thresholds for domestic and international trade of these chemicals not mentioned.Thus,he authorities will regulate all transactions involving these chemicals, regardless of size. Chemical mixtures containing any of these three chemicals, regardless of concentration, are not exempt from regulatory requirements.

he Drug Enforcement Administration is proposing to designate 3,4-MDP-2-P methyl glycidate (PMK glycidate), including its optical and geometric isomers; 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid), including its salts, optical and geometric isomers, and salts of isomers; and alpha-phenylacetoacetamide (APAA), including its optical isomers, as list I chemicals under the Controlled Substances Act (CSA).

The Drug Enforcement Administration is finalizing a December 21, 2020, notice of proposed rulemaking to designate three chemicals, known as PMK glycidate, PMK glycidic acid, and APAA, as list I chemicals under the Controlled Substances Act (CSA).

PMK ethyl glycidate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical chemical production process.

The Drug Enforcement Administration is finalizing a December 21, 2020, notice of proposed rulemaking to designate three chemicals, known as PMK glycidate, PMK glycidic acid, and APAA, as list I chemicals under the Controlled Substances Act (CSA).

The Drug Enforcement Administration is proposing to designate 3,4-MDP-2-P methyl glycidate (PMK glycidate), including its optical and geometric isomers; 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid), including its salts, optical and geometric isomers, and salts of isomers; and alpha-phenylacetoacetamide (APAA), including its optical isomers, as list I chemicals under the Controlled Substances Act (CSA).

For the reasons discussed above, the Acting Administrator of DEA finds that PMK glycidate, PMK glycidic acid, and APAA are used in the manufacture of a controlled substance in violation of the CSA, and are important to the manufacture of these controlled substances. Therefore, the Acting Administrator proposes the designation of PMK glycidate, PMK glycidic acid, and APAA as list I chemicals.

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