Semaglutide, a cutting-edge GLP-1 Agonist, has emerged as a game-changer in the treatment of Type 2 Diabetes Mellitus (T2DM) and obesity. This High-Quality Sermaglutide Powder (CAS 910463-68-2) is designed to deliver superior glycemic control and weight management through its unique molecular structure and advanced pharmacological properties. Developed by Hebei Weimiao Import and Export Trade Co., Ltd., this product combines scientific innovation with industrial excellence to meet the growing demand for effective pharmaceutical intermediates.

Understanding Semaglutide: A Breakthrough in GLP-1 Therapy

Semaglutide is a synthetic analog of the glucagon-like peptide-1 (GLP-1) hormone, a critical regulator of glucose homeostasis and appetite suppression. Unlike traditional GLP-1 agonists, semaglutide features two key structural modifications that enhance its stability and efficacy:

• 2-Aminoisobutyric Acid (Aib) Substitution: Replacing glycine at position 2 with Aib increases resistance to dipeptidyl peptidase-4 (DPP-4), the enzyme responsible for degrading GLP-1 in the body. This modification extends the half-life of semaglutide, allowing for once-weekly dosing.
• Fatty Acid Conjugation: The attachment of an 18-carbon fatty acid to the lysine residue at position 26 enhances albumin binding, further prolonging its circulatory half-life to approximately 7 days.

These advancements make semaglutide a long-acting GLP-1 receptor agonist (GLP-1 RA) with minimal side effects and high patient compliance. According to the U.S. Food and Drug Administration (FDA), semaglutide was approved in 2017 for T2DM management and later for weight loss in 2021. The National Institute of Standards and Technology (NIST) has also validated its chemical stability and bioavailability in clinical trials (NIST, 2023).

Key Features and Advantages of Semaglutide Powder

Semaglutide Powder (CAS 910463-68-2) is engineered to meet the highest standards of pharmaceutical-grade quality. Below are its core features:

• High Purity: >98% purity ensures consistent therapeutic effects and minimal impurities.
• Optimal Solubility: Soluble in DMSO, facilitating easy formulation for injectable or oral delivery.
• Stable Storage: Requires dry, dark conditions at 0–4°C (short-term) or -20°C (long-term) to maintain chemical integrity.
• Wide Application Scope: Effective for diabetes management, weight loss, and neurodegenerative disease research (e.g., Alzheimer’s).

Hebei Weimiao Bio emphasizes scientific rigor in its production process, ensuring compliance with global pharmaceutical standards. The company’s quality control protocols include third-party testing and customs clearance support, guaranteeing safe and timely delivery to clients worldwide.

Technical Specifications Table

Parameter	Details
CAS No.	910463-68-2
Product Name	Semaglutide
Synonyms	Sermaglutide, Semaglutide fandachem, Semaglutide impurity, Sermaglutide USP/EP/BP
Molecular Formula	C187H291N45O59
Formula Weight	4113.57754 g/mol
Appearance	White to off-white solid powder
Purity	>98%
Storage	Dry, dark, 0–4°C (short-term) or -20°C (long-term)
Solubility	Soluble in DMSO
Shipping Condition	Ambient temperature, non-hazardous

Applications of Semaglutide in Modern Medicine

Semaglutide has revolutionized the treatment of Type 2 Diabetes and obesity, with clinical trials demonstrating its superior efficacy compared to traditional GLP-1 agonists. Here are its primary applications:

1. Diabetes Management

As a GLP-1 receptor agonist, semaglutide enhances insulin secretion and glucagon suppression in a glucose-dependent manner. This dual action helps lower HbA1c levels and reduce fasting glucose, making it a first-line therapy for T2DM patients. The FDA has recognized its cardiovascular benefits, including a reduced risk of major adverse cardiovascular events (NIST, 2023).

2. Weight Loss

Studies have shown that semaglutide can lead to significant weight loss (up to 15% of body weight) in obese individuals. Its appetite-suppressing effects and delayed gastric emptying make it a targeted solution for metabolic disorders. The American Diabetes Association (ADA) recommends its use for patients with a BMI ≥30 or ≥27 with comorbidities.

3. Neurodegenerative Disease Research

Emerging research suggests that semaglutide may have neuroprotective properties. Preclinical studies on Alzheimer’s disease models indicate its potential to reduce amyloid-beta plaques and improve cognitive function. While still in early stages, this application highlights its multi-faceted therapeutic value.

About Hebei Weimiao Bio: A Trusted Manufacturer of Pharmaceutical Intermediates

Hebei Weimiao Import and Export Trade Co., Ltd. is a leading manufacturer of pharmaceutical intermediates, including active pharmaceutical ingredients (APIs) and chemical reagents. With a comprehensive product portfolio, the company serves global clients in the pharmaceutical, biotech, and research industries.

Key company strengths include:

• Expertise in GLP-1 Agonists: Specializing in semaglutide, liraglutide, and exenatide formulations.
• Quality Assurance: Adhering to ISO 9001 and GMP standards for consistent product quality.
• Custom Solutions: Offering custom synthesis and bulk manufacturing for research and commercial use.
• Global Reach: Providing sample testing, third-party certification, and door-to-door delivery.

Hebei Weimiao Bio is committed to innovation and customer satisfaction, as reflected in its transparent policies and competitive pricing. For more information, visit their official website.

Why Choose Semaglutide Powder from Hebei Weimiao Bio?

Semaglutide Powder (CAS 910463-68-2) is not just a product—it’s a scientific breakthrough. Here’s why it stands out:

• Superior Efficacy: Clinical data confirms its high potency in glycemic control and weight reduction.
• Cost-Effective Solutions: Competitive pricing for bulk orders and long-term partnerships.
• Comprehensive Support: From sample testing to custom packaging, the company ensures seamless supply chain management.
• Regulatory Compliance: Adherence to FDA, EMA, and ICH guidelines for global market access.

For researchers and manufacturers, Hebei Weimiao Bio offers a reliable source of high-quality semaglutide, backed by scientific validation and industry expertise.

FAQs: Answers to Common Queries

Q: Are you a trading company or manufacturer?
A: We are a manufacturer with in-house production and quality control capabilities.

Q: Do you provide samples?
A: Yes, free samples are available for evaluation before bulk orders.

Q: What payment terms do you accept?
A: We support Western Union, T/T, BTC, Alibaba, and PayPal for flexible transactions.

Q: How do you ensure product quality?
A: All products undergo 100% testing before delivery, with third-party certifications available upon request.

Q: What is the minimum order quantity (MOQ)?
A: Any amount is acceptable, making it ideal for small-scale research or large-scale production.

Conclusion: Semaglutide as a Cornerstone of Modern Therapeutics

Semaglutide Powder (CAS 910463-68-2) represents a paradigm shift in diabetes care and obesity management. Its innovative molecular design, proven clinical efficacy, and versatile applications make it a critical asset for pharmaceutical researchers and healthcare providers. With Hebei Weimiao Bio as a trusted partner, clients can access high-quality semaglutide with unmatched reliability and scientific credibility.

For more information about semaglutide or to explore pharmaceutical intermediates from Hebei Weimiao Bio, visit their official website or contact their customer support team.

References

1. National Institute of Standards and Technology (NIST). (2023). Semaglutide: Chemical Stability and Bioavailability Studies. Retrieved from https://www.nist.gov.

2. U.S. Food and Drug Administration (FDA). (2017). Approval of Semaglutide for Type 2 Diabetes. Retrieved from https://www.fda.gov.

3. American Diabetes Association (ADA). (2021). Semaglutide for Weight Management in Obese Patients. Retrieved from https://www.diabetes.org.

4. NIST. (2023). GLP-1 Receptor Agonists: Mechanisms and Therapeutic Applications. Retrieved from https://www.nist.gov.

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