• Do you want to become a Vendor to the High Potential Fast Growing Industry having Highest Contribution to the Society?
• Are you interested in Manufacturing High Profit Chemical Products with High Market Potential?
• Are you interested in a Manufacturing Business where the Capital Investment is low while the Sales Turnover is High?

If your answer to any of the questions is 'Yes', you must consider manufacturing Pharmaceutical Intermediates. Why?

Because you need Pharmaceutical Intermediates to manufacture the Active Pharmaceutical Ingredients.

But why the Active Pharmaceutical Ingredients are Important?

Powerful Medicines

Just think about the Powerful Medicines which save you from Life-Threatening diseases.

Do you know why they’re so effective against the diseases?

They’re effective because their power comes from the active pharmaceutical ingredients. In fact, these powerful medications are formulated with active pharmaceutical ingredients. Because these active molecules actually fight with the diseases.

No doubt the medicines are essential to save us from dangerous diseases. But they must be manufactured at large scale in sufficient quantities at reasonable costs. Why? 

Because all of us can’t take the advantage of them and it won’t serve any useful purpose unless they’re available at affordable prices.

And in order to make the medicines available at affordable prices, you need to manufacture high quality active pharmaceutical ingredient molecules at low costs. Why?

As we’ve mentioned earlier, active pharmaceutical ingredients make the medicines powerful. That’s why the availability and the cost of the medicines will depend on the availability and the cost of the active pharmaceutical ingredients. Isn’t it?

So the challenge is to make active pharmaceutical ingredients in sufficient quantities at low costs. Right?

When you get into the details of the manufacturing processes used in making active pharmaceutical ingredient molecules, you’ll find most of them involve chemical synthesis.

But when you think about synthesizing them, you find them to be challenging. Why?

It’s because the synthesis process involves multiple reaction steps along with complex reactions.

So how to make the manufacturing of active pharmaceutical ingredient molecules easy?

That’s where the pharmaceutical intermediates come into the picture.

Pharmaceutical Intermediates

In fact, when you talk about the multi-step synthesis, the manufacturing processes become complex and difficult. Why?

It’s because you need to start with the basic molecules – the chemical feedstock. Then you need to go through multiple synthesis steps to make the final active pharmaceutical ingredients molecule.

As we’ve mentioned earlier most of the synthesis processes are based on chemical reactions. But the issue is  most of the active pharmaceutical ingredients manufacturers are reluctant to make the molecules from the basic stage. Why?

It’s because multi-step synthesis involve different types of unit processes and unit operations along with handling the intermediates of various synthetic stages. And you need to carry out multiple processes and use multiple process equipments. You will need specialized equipments especially for difficult synthesis processes.

 If you get into the details of the synthesis processes used for making active pharmaceutical ingredients molecules, you’ll find that most of them are complex calling for expertise in many areas.

That’s precisely where the intermediate molecules become useful in manufacturing. The active pharmaceutical ingredients manufacturers procure the relevant intermediate molecules and make their product using one or two simple synthesis steps.

These intermediate molecules are nothing but Pharmaceutical Intermediates.

These Pharmaceutical Intermediates are classified into two categories:

• Basic Pharmaceutical Intermediate
• Advanced Pharmaceutical Intermediate

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Basic Pharmaceutical Intermediate

When you talk about the basic pharmaceutical intermediates, they’re relatively simple and made by using few synthesis steps from the basic chemical feed stock.

They can be used in two situations:

• If you’re interested in manufacturing active pharmaceutical ingredients molecules which are structurally simpler, basic pharmaceutical intermediates can serve the purpose. Because the manufacturer can conduct few simple synthesis steps and make the active pharmaceutical ingredients molecule.
• But even if the end product molecule is structurally complex, some manufacturers go for the basic pharmaceutical intermediates. Why? Because they want to manufacture their products at lower costs.

Especially when the manufacturers have the manufacturing facilities and expertise to handle multiple synthesis steps, making active pharmaceutical ingredients molecule makes business sense.

Advanced Pharmaceutical Intermediate

When you talk about the advanced pharmaceutical intermediate molecules, they’re are structurally complex. That’s why they’re made by using multiple synthesis steps involving specialized unit processes and unit operations. Of course, they’re expensive. But they’ve got their own applications.

They can be used in two situations:

• If you’re interested in manufacturing active pharmaceutical ingredients molecules which are structurally very complex, advanced pharmaceutical intermediates can only serve the purpose.
• Because if you use basic pharmaceutical intermediates here, your manufacturing process will involve multiple specialized synthesis steps. And most of the active pharmaceutical ingredient manufacturers don’t have the manufacturing facilities and expertise to handle multiple synthesis steps.

Most of the active pharmaceutical ingredient molecules sell at high prices. In that situation, when the manufacturers do the product costing, they find the cost contribution of the advanced pharmaceutical intermediates is not significant. That’s why they’re ready to pay for these molecules rather than manufacturing themselves.

Why Pharmaceutical Intermediates?

Now, let’s come to the main point. Does it make business sense to manufacture pharmaceutical intermediates?

Because when you think as an entrepreneur, you’ll find that two things can make the difference between success and failure of any business.

Let’s list then down:

• Good Market Prospects
• The Business must be Profitable

First of all, let’s get into the details of the market prospects…

Good Market Prospects

When you talk about the market prospects of pharmaceutical intermediates, it depends on the market for the active pharmaceutical ingredients. When it comes to the market of active pharmaceutical ingredients, it’s growing at a fast pace.

Of course, the reasons are many. Let’s talk about some of them:

• It’s a fact that most of the diseases are very serious and you must start medical treatment as early as possible. Long term medication becomes necessary in many cases. In fact, because of increased health awareness, medicine consumption is increasing rapidly.
• Today the income levels of people have increased significantly. It’s helping more and more people to afford quality medicines. In fact, they’re now reluctant to ignore the diseases and ready to spend on medication. And it has resulted in increased medicine consumption.

The increased consumption of medicines have made the demand for active pharmaceutical ingredients very high. As the demand of pharmaceutical intermediates is directly linked with the demand of active pharmaceutical ingredients, there’s good market prospects for them.

Now, it’s time to talk about the business profitability.

The Business must be Profitable

Today, the profitability of manufacturing pharmaceutical intermediates is very high.

And it’s because of multiple factors:

• With the advances in the medical research, more and more active pharmaceutical ingredient molecules are getting added to the list. As multiple pharmaceutical intermediates are required to make active pharmaceutical ingredient, you have got wide choice. You can choose the right molecule to manufacture based on techno-commercial factors in order to maximize the profitability.
• More and more advanced technologies are available now. They’ve made it easy to make the complex molecules at low manufacturing costs.
• When you use advanced technologies to manufacture the pharmaceutical intermediates molecules and make them from low priced chemical feedstocks, you can improve the profitability significantly. In fact, here you’re making high priced products from low-cost raw materials.
• With manufacturing pharmaceutical intermediates, you can achieve high sales turnover while making the capital investment low. It’ll result in significant reduction in the financial cost and increase in profitability.
• And with pharmaceutical intermediates manufacturing, demand supply gap is significant. In fact, the supply doesn’t match the demand for many molecules resulting in the increase in the selling prices.

So, it’s an incredible business opportunity. Isn’t it? The important question here is how to utilize the opportunity to the fullest.

But before getting ahead further, let’s see how the pharmaceutical intermediates molecules are manufactured.

Manufacturing Process

As we’ve discussed earlier. the manufacturing processes involve multiple unit processes and unit operations to convert the raw materials into the finished products. And most of the times the raw material molecules are changed to make new molecules.

When you study the manufacturing processes of pharmaceutical intermediates molecules, you’ll find four different types:

• Chemical Synthesis
• Fermentation Process
• Enzymatic Reaction
• Extraction from Natural Sources

But most of the manufacturing processes of pharmaceutical intermediates molecules, involve chemical synthesis.

Option for Chemical Manufacturers

As we’ve discussed earlier, today manufacturing pharmaceutical intermediates has emerged as a profitable option especially for the leading chemicals manufacturers. Why?

There’re various reasons. However, we shall discuss about a few of them:

Expertise in Unit Processes and Unit Operations

As a chemical manufacturer, you have already developed expertise in difficult unit processes as well as unit operations. In fact, the pharmaceutical intermediates are chemical products.

So why not take the advantages of your expertise in manufacturing the pharmaceutical intermediates? In fact, you can make them more efficiently.

Safety and Environment Systems

Since you’re involved in chemical manufacturing, the safety and environment systems are in place.  And you’ve already optimized them. The manufacturing processes of most of the pharmaceutical intermediates generate wastes.

So why not utilize your expertise in environmental management? In fact you’re in a better position to handle the waste streams and make use of the byproducts and coproducts optimally.

Of course, you can take the advantages of integrated manufacturing by Process Integration as well as Energy Integration.

Selecting Pharmaceutical Intermediates

When you talk about pharmaceutical intermediates manufacturing, selecting the right molecules is the starting point. But it’s the most important aspect of your manufacturing business. Why?

Because most of the critical aspects of your business gets decided once you finalize the molecules to manufacture. In fact, it can make the difference between success and failure.

But how to select the right pharmaceutical intermediate molecules?

Especially when it comes to the chemical manufacturers, the selection becomes more important. Because you’re not starting from the scratch. You have already chemical manufacturing facilities and experience in making chemical products.

That’s why you must utilize the resources available to you optimally.  

Let’s come back to what we were discussing – product selection. In fact, the product selection is challenging. Why? Because looking to the dynamic business environment, in order to select the right molecule, you need to go for detailed analysis of the technical and commercial aspects.

Let’s talk about some important techno-commercial aspects.

• In fact, the most important is to check the present market demand and see what’ll be the future prospects.
• And you can’t ignore the raw materials. What about the availability of the raw materials including the purchase price and quality?
• You must search for the best available technologies and the status of advanced research in the field.
• It’s important to check the technical feasibility and economical viability of meeting the pollution control requirements.
• Special focus must be on ensuring the process safety. Because safety comes first.
• Another equally important part is to ensure environmental sustainability.
• But will you be able to meet the quality requirements of the customers and preferably at lower manufacturing cost. In fact, it’s important to match the selling prices (considering the market fluctuations) with the cost of manufacturing.

In fact, in any manufacturing business product applications are of utmost importance.

When it comes to the pharmaceutical intermediates, they’re used as key starting materials for manufacturing active pharmaceutical ingredients. But they don’t have any direct use. Because they’re never used directly in formulating pharmaceutical products. That’s why the product quality must meet the requirements of the active pharmaceutical ingredient manufacturers.

Medication Categories

As we’ve mention earlier, the market demand for effective medication is going up day by day. So the market demand for active pharmaceutical ingredients are increasing very fast.

And different active pharmaceutical ingredients cater to different medication categories. You can consider them for evaluating the pharmaceutical intermediates molecules to manufacture.

Some of the medication categories are mentioned below:

• Antibiotics
• Antifungal Molecules
• Antiviral Molecules
• Antiparasitic Molecules
• Antihypertensive molecules
• Antiplatlet agents
• Anticoagulants
• Cholesterol lowering agents
• Antidiabetic Molecules
• Anticancer Molecules
• Proton Pump Inhibitors
• Pain Killers
• Vitamins and Nutraceuticals

When you’ve the adequate information on the type of medicines used against the diseases, you can think of the which pharmaceutical intermediates are in demand.

It’ll help you a lot to estimate their markets. Of course, there are thousands of active pharmaceutical ingredients used against a wide number of diseases.

If you study the manufacturing processes of active pharmaceutical ingredients, you’ll find multiple pharmaceutical intermediates are used for a single molecule. So you can always select the right pharmaceutical intermediates for your manufacturing business and add value.

Of course, you must have detailed knowledge on the synthesis processes to evaluate the molecules thoroughly. But you have got choice. Isn’t it?

Though the things are difficult, it offers incredible opportunities especially innovation focused manufacturers. Why?

Because if you can identify the techno-commercial incongruences, you can develop great profit-making ideas and add massive value to your manufacturing business. But you must be knowledgeable about pharmaceutical ingredients manufacturing.

For that you need to study the manufacturing processes of hundreds of pharmaceutical ingredients. And you need to make massive efforts to collect techno-commercial information and evaluate them following an innovative and integrated approach. Why?

Because that’s essential to optimize the diverse business aspects and extract meaningful conclusion. But the outcome will surprise you. It’ll be easy for you to select extremely profitable pharmaceutical ingredients for manufacturing.

Let’s Conclude

The best way to get associated with the High Potential Fast Growing Pharmaceutical Industry is to manufacture Pharmaceutical Intermediates. Why?

Because it’ll help you not only to achieve Business Success but also to Contribute to the Society significantly. The modern world can’t sustain without Medications.

As an Entrepreneur, it’s important for you to make the Medicines available at affordable prices, by manufacturing high quality Pharmaceutical Intermediates at low costs. Why?

Because you need Pharmaceutical Intermediates to manufacture the Active Pharmaceutical Ingredients which are the Active Components of the Powerful Medications and actually fight with the diseases.

The Pharmaceutical Intermediates are classified into two categories:

• Basic Pharmaceutical Intermediate
• Advanced Pharmaceutical Intermediate

From an entrepreneur’s perspective manufacturing Pharmaceutical Intermediates makes business sense because of the Market and Business Profitability.

In order to be successful in Pharmaceutical Intermediates Manufacturing, you must Select the Right Molecule and the Process Technology to manufacture them Profitably and Sustainably.

But it’s quite challenging. You need to consider many conflicting techno-commercial aspects in order to arrive at the best possible solutions. In fact, you need to follow an innovative approach based on integrated optimization.

That's where the Process industry innovations comes into the picture.

Process industry innovations are powerful enough to achieve the desired improvements.

Once you implement the innovation initiatives in your Pharmaceutical Intermediates Manufacturing Business, you yourself will be convinced that it works.

Let’s join hands in using Process industry innovations and developing them further in order to make the Manufacturing Business Profitable and Sustainable.

Perhaps you can consider taking the help of Industry Experts to make the process fast and effective.