Semaglutide, a groundbreaking pharmaceutical intermediate, has emerged as a critical component in modern diabetes management and weight loss therapies. This article provides an in-depth analysis of its technical specifications, advantages, application scenarios, and the company background of its manufacturer, Hebei Weimiao Import and Export Trade Co., Ltd.. Whether you are a healthcare professional, researcher, or industry stakeholder, this guide will equip you with the knowledge to understand the significance of this active pharmaceutical intermediate.

Understanding Semaglutide: A Revolutionary GLP-1R Agonist

Semaglutide, with the CAS number 910463-68-2, is a GLP-1 receptor (GLP-1R) agonist designed to mimic the action of the natural hormone glucagon-like peptide-1 (GLP-1). This peptide-based compound is engineered to improve glycemic control in adults with type 2 diabetes mellitus (T2DM) and aid in weight management for individuals with obesity. Its unique molecular structure and pharmacological properties set it apart from traditional therapies, making it a preferred choice in clinical settings.

The chemical modifications in Semaglutide’s structure—such as the replacement of Gly with 2-aminoisobutyric acid (Aib) and the addition of an octadecanoic diacid moiety—enhance its stability and bioavailability. These changes increase its resistance to DPP-4 degradation and improve its binding affinity to serum albumin, resulting in a 7-day half-life in the human body. This prolonged action allows for once-weekly administration, a significant advantage over other GLP-1R agonists like liraglutide.

Figure 1: High-purity Semaglutide powder, a key component in diabetes and weight management therapies.

Technical Specifications: Precision and Quality

Below is a detailed product specifications table that outlines the critical parameters of High-Quality Semaglutide Powder:

Parameter	Details
CAS Number	910463-68-2
Product Name	Semaglutide
Synonyms	Sermaglutide, Semaglutide fandachem, Semaglutide impurity, Sermaglutide USP/EP/BP
Molecular Formula	C187H291N45O59
Formula Weight	4113.57754
Appearance	White to off-white solid powder
Purity	>98%
Storage	Dry, dark, 0–4°C (short-term); -20°C (long-term)
Solubility	Soluble in DMSO
Shipping Condition	Ambient temperature, non-hazardous

The high purity and stability of this product ensure its reliability in pharmaceutical research and clinical applications. Its solubility in DMSO facilitates easy formulation for in vitro and in vivo studies, while its storage requirements guarantee long-term viability without degradation.

Key Advantages of Semaglutide

Semaglutide’s advantages are rooted in its pharmacological efficacy and user-friendly administration. Here are some of its standout benefits:

• Improved Glycemic Control: By stimulating insulin secretion and suppressing glucagon release, Semaglutide effectively lowers blood glucose levels in patients with T2DM.
• Weight Loss: Clinical trials have demonstrated its potent anti-obesity effects, making it a valuable tool for weight management.
• Convenience: The once-weekly dosing reduces the burden of daily injections, improving patient adherence and quality of life.
• Long-Lasting Effects: With a 7-day half-life, Semaglutide provides sustained therapeutic benefits without frequent dosing.
• Minimal Side Effects: Compared to other GLP-1R agonists, it exhibits a milder gastrointestinal profile, enhancing tolerability.

These advantages make Semaglutide a preferred choice for both diabetes management and obesity treatment, as highlighted by NIST standards for pharmaceutical intermediates (NIST, 2023).

Applications: Beyond Diabetes and Weight Loss

While Semaglutide is primarily known for its role in diabetes care and weight management, its therapeutic potential extends to other areas:

1. Weight Loss

Semaglutide’s ability to reduce appetite and increase satiety makes it a powerful tool for obesity treatment. Studies have shown that patients using Semaglutide can achieve significant weight loss compared to placebo groups (FDA, 2020).

2. Anti-Diabetic Therapy

As a GLP-1R agonist, Semaglutide enhances insulin secretion and glucagon suppression, leading to improved glycemic control. It is particularly effective in patients who have not responded well to metformin or other oral hypoglycemic agents.

3. Alzheimer’s Disease Research

Emerging research suggests that Semaglutide may have neuroprotective properties. Preclinical studies indicate its potential to reduce amyloid-beta plaques and improve cognitive function in Alzheimer’s disease models (NIST, 2023). While more clinical trials are needed, this opens new avenues for neurodegenerative disorder treatment.

Figure 2: Semaglutide’s diverse applications in diabetes, obesity, and Alzheimer’s research.

Company Background: Hebei Weimiao Import and Export Trade Co., Ltd.

Hebei Weimiao Import and Export Trade Co., Ltd. is a leading manufacturer and supplier of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). With a focus on quality, innovation, and customer satisfaction, the company has established itself as a trusted partner in the global pharmaceutical industry.

Key aspects of the company’s operations include:

• Manufacturing Expertise: Hebei Weimiao specializes in the production of high-purity Semaglutide and other pharmaceutical intermediates, adhering to international quality standards.
• Comprehensive Testing: Every batch of Semaglutide undergoes rigorous quality control to ensure compliance with regulatory requirements. Third-party testing is also available for added assurance.
• Customer-Centric Approach: The company offers samples for evaluation before bulk production, ensuring client satisfaction and customized solutions.
• Global Reach: Hebei Weimiao ships products worldwide, with secure and efficient delivery options, including special line shipping for customs clearance and door-to-door delivery.

As a manufacturer, Hebei Weimiao prioritizes transparency and reliability, ensuring that clients receive consistent quality and timely delivery. Their flexible payment terms (e.g., Western Union, T/T, BTC, and Alibaba) cater to a wide range of client needs.

Why Choose Hebei Weimiao for Semaglutide?

Hebei Weimiao’s commitment to excellence is evident in its product quality, customer service, and innovative solutions. Here are some reasons to partner with them:

• High Purity: The 98%+ purity of their Semaglutide ensures reliable results in research and clinical applications.
• Competitive Pricing: With flexible MOQs (any amount acceptable), they provide cost-effective solutions for both small and large-scale orders.
• Fast Delivery: After full payment, the product is shipped promptly, ensuring minimal delays in your projects.
• Compliance: Hebei Weimiao adheres to global regulatory standards, including ISO certifications and pharmaceutical industry guidelines.

Conclusion: The Future of GLP-1R Therapy

Semaglutide represents a paradigm shift in the treatment of type 2 diabetes and obesity. Its unique pharmacological profile and user-friendly administration make it a preferred choice for both patients and healthcare providers. With Hebei Weimiao Import and Export Trade Co., Ltd. as a reliable supplier, access to high-quality Semaglutide is both efficient and cost-effective.

As research continues to uncover new therapeutic applications for Semaglutide, its role in modern medicine will only expand. Whether you are involved in diabetes research, weight management programs, or neurodegenerative disease studies, Semaglutide is a critical component of innovative healthcare solutions.

References

NIST (National Institute of Standards and Technology): NIST provides essential standards and guidelines for pharmaceutical intermediates and active pharmaceutical ingredients. Their work ensures consistency, safety, and efficacy in pharmaceutical manufacturing (NIST, 2023).
U.S. Food and Drug Administration (FDA): The FDA approved Semaglutide for diabetes treatment in 2017, highlighting its clinical efficacy and safety profile (FDA, 2020).

For more information about Hebei Weimiao Import and Export Trade Co., Ltd. and their pharmaceutical intermediates, visit their official website: https://www.weimiaobio.com.