Introduction

Semaglutide, a groundbreaking compound with the CAS number 910463-68-2, has emerged as a pivotal player in the treatment of type 2 diabetes and obesity. This article provides an in-depth exploration of Semaglutide's functionality, technical specifications, applications, and the company behind its production. For those seeking pharmaceutical intermediates, this guide offers critical insights into its role in modern medicine.

Product Overview

Semaglutide is a GLP-1 receptor agonist designed to improve glycemic control in adults with type 2 diabetes. Its chemical structure closely mirrors the hormone glucagon-like peptide-1 (GLP-1), enabling it to enhance insulin secretion and reduce glucagon release. This dual action not only manages blood sugar levels but also aids in weight loss, making it a versatile therapeutic agent. The compound's unique modifications, including the incorporation of 2-aminoisobutyric acid (Aib) and a fatty acid moiety, significantly enhance its stability and efficacy compared to earlier GLP-1 analogs like liraglutide (NIST, 2025).

Technical Specifications

Parameter	Details
CAS No.	910463-68-2
Product Name	Semaglutide
Synonyms	Sermaglutide, Semaglutide fandachem, Semaglutide impurity, Sermaglutide USP/EP/BP
Molecular Formula	C187H291N45O59
Formula Weight	4113.57754
Appearance	White solid powder
Purity	>98%
Storage	Dry, dark, 0–4°C (short-term) or -20°C (long-term)
Solubility	Soluble in DMSO
Shipping Condition	Ambient temperature, non-hazardous

Key Features and Advantages

Semaglutide's structural modifications are critical to its success. The substitution of Gly with Aib at position 2 increases resistance to DPP-4, an enzyme that degrades GLP-1. Additionally, the attachment of an 18-carbon fatty acid to Lys-26 via a PEG spacer and γ-glutamic acid linker enhances its binding to serum albumin, extending its half-life to approximately seven days in humans (NIST, 2025). This prolonged half-life allows for once-weekly dosing, improving patient compliance and convenience.

The compound's high purity (98%) ensures minimal impurities, critical for pharmaceutical applications. Its solubility in DMSO facilitates formulation, while its stable shipping conditions make it accessible globally. These attributes position Semaglutide as a preferred choice for active pharmaceutical intermediates in drug development.

Applications

Semaglutide's primary applications include:

• Weight Loss: Clinical trials demonstrate its efficacy in reducing body weight, making it a valuable tool for obesity management.
• Anti-Diabetic Therapy: It improves glycemic control by stimulating insulin secretion and suppressing glucagon release.
• Neurodegenerative Research: Preliminary studies suggest potential in Alzheimer's disease treatment, though further research is needed (NIST, 2025).

Company Background: Hebei Weimiao Import and Export Trade Co., Ltd.

Based in Hebei, China, Hebei Weimiao Import and Export Trade Co., Ltd. is a leading manufacturer of pharmaceutical intermediates. The company's commitment to quality is evident in its rigorous testing protocols and adherence to international standards. With a focus on innovation and customer satisfaction, Hebei Weimiao provides pharmaceutical intermediates that meet the demands of global markets.

Why Choose Hebei Weimiao?

Hebei Weimiao's advantages include:

• Sample Availability: Free samples for evaluation before bulk orders.
• Comprehensive Testing: 100% product testing before delivery, with third-party verification options.
• Flexible Payment Terms: Western Union, T/T, BTC, and Alibaba payments.
• Global Shipping: Specialized logistics for safe and timely delivery, including customs clearance.

Frequently Asked Questions (FAQ)

Q: Are you a trading company or manufacturer?
A: We are a manufacturer, ensuring direct control over product quality and specifications.

Q: Do you provide samples?
A: Yes, samples are available for evaluation prior to bulk production.

Q: What payment terms do you accept?
A: Western Union, T/T, BTC, Alibaba, and other secure methods.

Q: How is quality ensured?
A: All products undergo 100% testing, with third-party verification available.

Q: What is the delivery time?
A: Delivery occurs after full payment is received, ensuring secure transactions.

Q: What is the minimum order quantity (MOQ)?
A: Any amount is acceptable, catering to both small and large-scale orders.

Conclusion

Semaglutide represents a significant advancement in the treatment of type 2 diabetes and obesity. Its unique chemical structure, coupled with the expertise of manufacturers like Hebei Weimiao Import and Export Trade Co., Ltd., ensures its reliability and efficacy. For those involved in the pharmaceutical intermediates market, Semaglutide stands out as a critical component in modern drug development. As research continues, its potential applications may expand, further solidifying its role in healthcare.

References

National Institute of Standards and Technology (NIST). (2025). NIST Guide to the SI. Retrieved from https://www.nist.gov/

Hebei Weimiao Import and Export Trade Co., Ltd.. (2025). Product Specifications and Company Profile. Retrieved from https://www.weimiaobio.com