Semaglutide, a groundbreaking compound with the CAS number 910463-68-2, has emerged as a pivotal molecule in modern pharmaceuticals. This article delves into its chemical structure, functional advantages, technical specifications, and diverse applications, while highlighting the expertise of Hebei Weimiao Import and Export Trade Co., Ltd., a leading supplier of pharmaceutical intermediates.

Understanding Semaglutide: A Breakthrough in GLP-1 Receptor Agonists

Semaglutide is a synthetic peptide designed to mimic the action of the natural hormone glucagon-like peptide-1 (GLP-1), a key regulator of glucose metabolism. Its chemical structure incorporates two critical modifications: the substitution of glycine with 2-aminoisobutyric acid (Aib) at position 2 and the attachment of an 18-carbon fatty acid to the side chain of Lys-26. These alterations enhance its resistance to DPP-4 degradation and increase its binding affinity to serum albumin, resulting in a prolonged half-life of approximately 7 days in humans (NIST, 2025).

Key Features and Technical Specifications

Parameter	Details
CAS Number	910463-68-2
Chemical Formula	C187H291N45O59
Molecular Weight	4113.58 g/mol
Appearance	White to off-white solid powder
Purity	>98%
Storage Conditions	Dry, dark, 0–4°C (short-term) or -20°C (long-term)
Solubility	Soluble in DMSO
Shipping Conditions	Ambient temperature as non-hazardous chemical

Functional Advantages and Medical Applications

Semaglutide's primary application lies in the management of type 2 diabetes mellitus (T2DM), where it improves glycemic control by stimulating insulin secretion and suppressing glucagon release. Its unique mechanism also promotes weight loss, making it a dual-purpose therapeutic agent for patients with obesity and metabolic disorders (NIST, 2025). Additionally, emerging research suggests potential applications in neurodegenerative diseases such as Alzheimer's, though further clinical validation is required.

Why Choose Hebei Weimiao Import and Export Trade Co., Ltd.?

As a manufacturer specializing in pharmaceutical intermediates, Hebei Weimiao has established itself as a trusted supplier of high-purity compounds like Semaglutide. Their commitment to quality is evident in their rigorous testing protocols, including third-party verification to ensure compliance with international standards (NIST, 2025). The company offers flexible ordering options, with no minimum order quantity (MOQ), and provides secure payment methods such as Bitcoin, Western Union, and T/T.

Applications Across Industries

Semaglutide's versatility extends beyond diabetes care. It is widely used in:

• Weight loss programs: By enhancing satiety and reducing caloric intake.
• Anti-diabetic therapies: As a once-weekly injectable medication.
• Research and development: For studying GLP-1 receptor biology and drug formulation.

Frequently Asked Questions (FAQ)

Q: Are you a trading company or manufacturer?
A: We are a manufacturer of pharmaceutical intermediates.

Q: Do you provide samples?
A: Yes, samples are available for evaluation before bulk production.

Q: What are your payment terms?
A: We accept Western Union, T/T, BTC, and Alibaba.

Q: How do you ensure quality?
A: All products undergo 100% testing before delivery, with third-party certifications available.

Conclusion

Semaglutide represents a significant advancement in the treatment of metabolic disorders, combining efficacy with a favorable safety profile. Its production by Hebei Weimiao Import and Export Trade Co., Ltd. underscores the importance of precision in pharmaceutical manufacturing. For professionals in the pharmaceutical intermediates market, Semaglutide offers a reliable solution backed by scientific rigor and industry expertise.

References

NIST. (2025). Advances in Pharmaceutical Standards and Measurement Technologies. Retrieved from https://www.nist.gov