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(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester, is a non-steroidal selective androgen receptor modulator (SARM), more commonly referred to as YK11. YK11 has shown potential in effectively increasing bone density and muscle mass while reducing fat mass. Studies have suggested that YK11 is able to improve osteoblast activity and bone density through activation of the protein kinase B.That being said, current research indicates that muscle growth caused by YK11 is due to increased levels of follistatin. Increased levels of follistatin lead to the inhibition of myostatin, a protein responsible for the regulation of muscle growth. With myostatin blocked as a result of YK11 treatment, there is no inhibition of potential muscle growth. The SARM is capable of eliciting responses in the anabolic pathways that are similar to those associated with traditional anabolic agents, testosterone and DHT.

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