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Sep . 21, 2024 17:58 Back to list

tosyl chloride cas 98-59-9 manufacturers



An Overview of Tosyl Chloride (CAS 98-59-9) and Its Manufacturers


Tosyl chloride, also known as p-toluenesulfonyl chloride, is a chemical compound widely used in organic synthesis and various industrial applications. Its chemical formula is C7H7ClO2S, and it is primarily recognized for its role as a sulfonating agent. This article delves into the properties, applications, and manufacturers of tosyl chloride (CAS 98-59-9), highlighting its significance in the chemical industry.


Properties of Tosyl Chloride


Tosyl chloride is a white to pale yellow crystalline solid that is hygroscopic in nature, readily absorbing moisture from the air. It has a molecular weight of 190.67 g/mol and a boiling point of approximately 177°C. The compound is soluble in a range of organic solvents, including dichloromethane, and exhibits a certain level of stability under normal conditions. However, it reacts vigorously with water, releasing hydrochloric acid and forming tosylamide or tosylates.


Applications of Tosyl Chloride


The versatility of tosyl chloride makes it a valuable reagent in organic chemistry. One of its most prominent uses is in the conversion of alcohols into tosylates, which are better leaving groups for nucleophilic substitution reactions. This transformation enhances the reactivity of alcohols, facilitating further chemical synthesis.


In addition to its role in nucleophilic substitution, tosyl chloride is also employed in peptide synthesis, where it serves as a coupling reagent. In this context, tosyl chloride can activate carboxylic acids for the formation of peptide bonds, thereby streamlining the synthesis of complex biomolecules.


Furthermore, tosyl chloride finds applications in the production of sulfonamide drugs, where it acts as a sulfonating agent. This class of compounds is vital in medicinal chemistry, contributing to the development of various pharmaceuticals.


tosyl chloride cas 98-59-9 manufacturers

tosyl chloride cas 98-59-9 manufacturers

Manufacturers of Tosyl Chloride


Numerous manufacturers globally produce tosyl chloride, catering to different market needs and applications. When selecting a supplier, companies often consider factors such as product quality, compliance with safety regulations, and the ability to meet delivery demands.


1. Alfa Aesar A well-known supplier in the chemical industry, Alfa Aesar provides high-purity tosyl chloride along with comprehensive technical support. Their commitment to quality and customer service has made them a preferred choice for many researchers and industrial clients.


2. Sigma-Aldrich This global leader in chemical manufacturing offers tosyl chloride with various packaging options, ensuring that users can acquire the product suited to their specific applications. Sigma-Aldrich is renowned for its rigorous quality control processes.


3. Tci Chemicals Tci Chemicals specializes in custom synthesis and offers a range of tosyl chloride products. Their focus on innovation and sustainability caters to the needs of companies looking for environmentally friendly chemical solutions.


4. Henan Tianfu Chemical A prominent manufacturer in China, Henan Tianfu Chemical produces tosyl chloride in bulk, supplying it to various industries worldwide. Their competitive pricing and reliable delivery make them a key player in the global market.


Conclusion


Tosyl chloride (CAS 98-59-9) is an essential reagent in organic synthesis, with numerous applications spanning pharmaceuticals and material science. Its production by various manufacturers underscores its importance in the chemical industry. As research and development continue to advance, the role of tosyl chloride will likely expand, making it a staple for chemists and industries alike.


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