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Dec . 10, 2024 06:19 Back to list

china phenacitin powder cas 62-44-2



Exploring Phenacetin Powder CAS 62-44-2


Phenacetin, a synthetic compound with the chemical formula C10H13NO2, is primarily known for its historical significance as a pharmaceutical analgesic and antipyretic agent. The compound was widely used for its pain-relieving properties until its activity was significantly overshadowed by concerns over safety and its link to adverse health effects. The CAS number for Phenacetin is 62-44-2, which serves as a unique identifier for the substance in chemical databases.


Historical Context


Phenacetin first gained prominence in the late 19th century, introduced as a substitute for aspirin. Its ability to reduce fever and relieve pain made it a go-to medication for various ailments, including headaches, muscle pain, and menstrual cramps. However, by the mid-20th century, reports began to emerge linking Phenacetin to serious health risks, particularly renal disorders and even cancer. These alarming findings forced many countries to reevaluate its safety, leading to its ban or restriction in numerous jurisdictions.


Chemical Properties

Phenacetin is a white, crystalline powder that is soluble in organic solvents but has limited solubility in water. Its melting point is around 134-135 °C, and it exhibits a slightly sweet taste. The molecule consists of a phenyl group attached to an acetylated amino group, which contributes to its pharmacological activity. As a member of the aniline derivatives, its structure is key to its chemical reactivity and interaction with biological systems.


Mechanism of Action


The analgesic properties of Phenacetin are primarily attributed to its conversion in the body to paracetamol (acetaminophen), which is a well-known pain reliever today. When ingested, Phenacetin undergoes metabolic processes that facilitate the conversion to paracetamol, exerting its effects predominantly by inhibiting cyclooxygenase (COX) enzymes, which are responsible for the production of prostaglandins—chemicals that promote inflammation, pain, and fever.


china phenacitin powder cas 62-44-2

china phenacitin powder cas 62-44-2

Contemporary Relevance


Today, the use of Phenacetin has dramatically declined due to its association with serious health risks. Alternatives such as ibuprofen and acetaminophen have largely replaced it in clinical practice, providing safer options for pain management. Nevertheless, Phenacetin remains a subject of academic interest due to its unique properties and historical role within the pharmacological landscape.


In some regions, Phenacetin may still be found listed in chemical databases and is used for research purposes, particularly in studies exploring its chemical properties and potential pharmacological applications. However, any experiments involving Phenacetin must prioritize safety, given its toxicological profile.


Safety and Toxicology


The safety profile of Phenacetin is a crucial aspect to consider, particularly for those handling the substance in laboratory settings. Prolonged use is associated with several adverse effects, including the risk of kidney damage and hematological abnormalities, such as methemoglobinemia. Its potential carcinogenicity has also been a significant concern, which led to regulatory agencies worldwide banning its use in over-the-counter medications.


Conclusion


Phenacetin, with the CAS number 62-44-2, serves as a fascinating case study within pharmaceutical history. While its initial reputation as an effective analgesic was marred by serious health concerns, the compound provides valuable insights into drug development, chemical safety, and the importance of rigorous pharmacological evaluation. For researchers and pharmaceutical chemists, Phenacetin remains a noteworthy example of how scientific progress is often accompanied by the need for ongoing vigilance regarding safety and efficacy. As we continue to learn from the past, the medical community must prioritize patient safety and the use of safer, more effective alternatives in pain management.


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