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Dec . 03, 2024 16:04 Back to list

3-chloropyridine cas 626-60-8



3-Chloropyridine An Overview of Its Properties, Applications, and Safety Considerations


3-Chloropyridine, a chemical compound with the CAS number 626-60-8, is an important member of the pyridine family. This colorless to yellowish liquid is characterized by a pyridine ring, which is a six-membered aromatic heterocycle featuring one nitrogen atom. The chlorine substituent at the third position of the ring plays a crucial role in defining the chemical's properties and its applications across various industries.


Chemical Properties


3-Chloropyridine has a molecular formula of C5H4ClN and a molecular weight of approximately 129.54 g/mol. It boasts a boiling point of around 153-154°C and a melting point of about -11.5°C. The compound is moderately soluble in water, and its solubility increases in organic solvents such as ethanol and acetone. Its chlorinated structure imparts certain unique characteristics compared to its non-chlorinated analogue, pyridine. Notably, the presence of chlorine enhances reactivity, enabling 3-chloropyridine to undergo various substitution reactions.


Production Methods


There are several methods for synthesizing 3-chloropyridine. One of the most common approaches is through the chlorination of pyridine using chlorine gas or other chlorinating agents. This reaction typically requires controlled conditions to ensure selectivity for the third position; other derivatives can be produced if conditions are not carefully optimized. Alternative methods involve the reaction of 3-pyridinemethanol with thionyl chloride or phosphorus trichloride, which also leads to the formation of 3-chloropyridine.


Applications


3-chloropyridine cas 626-60-8

3-chloropyridine cas 626-60-8

3-Chloropyridine is extensively used in the pharmaceutical industry as an intermediate in the synthesis of various biologically active compounds. It serves as a building block for numerous medications, including those related to cancer treatment, anti-inflammatory agents, and antibiotics. Furthermore, it has applications in the development of agrochemicals, particularly herbicides and insecticides, where its structure enhances biological activity.


In addition to its role in pharmaceuticals and agrochemicals, 3-chloropyridine finds use in the manufacture of dyes, pigments, and other specialty chemicals. Its reactivity allows it to participate in various organic transformations, making it a valuable compound for research and industrial purposes.


Safety Considerations


While 3-chloropyridine has numerous beneficial applications, it is essential to handle the compound with care due to its potential hazards. It is classified as a harmful substance, and exposure can occur through inhalation, skin contact, or ingestion. Symptoms of exposure may include respiratory irritation, skin burns, and damage to the liver and kidneys. Therefore, it is crucial to use appropriate personal protective equipment (PPE) when working with this compound.


In laboratory settings, safety data sheets (SDS) should be consulted to provide detailed information regarding its properties, handling procedures, and emergency measures. Proper ventilation, use of gloves, goggles, and laboratory coats are essential to minimize risks associated with 3-chloropyridine handling.


Conclusion


3-Chloropyridine is a versatile compound with significant importance in the fields of chemistry, pharmaceuticals, and agriculture. Its unique properties and structural characteristics contribute to its wide-ranging applications, facilitating the development of various chemical products. However, as with many chemical substances, it is crucial to prioritize safety and adhere to proper handling guidelines to mitigate risks associated with exposure. With continued research and development, compounds like 3-chloropyridine will likely play a pivotal role in future innovations across multiple industries.


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