• Introduction to 1-Bromodibenzothiophene and Industrial Significance
• Technical Specifications and Performance Advantages
• Global Supplier Comparison Analysis
• Custom Synthesis Solutions for Research Applications
• Quality Control Protocols in Manufacturing
• Industrial Applications Across Pharmaceutical Sectors
• Strategic Sourcing Approaches for CAS 65642-94-6 Materials

(cas 65642-94-6 1-bromodibenzothiophene)

Understanding 1-Bromodibenzothiophene (CAS 65642-94-6) in Modern Chemistry

Specialized heterocyclic compounds serve as critical building blocks in pharmaceutical development, with 1-bromodibenzothiophene (CAS 65642-94-6) emerging as a structurally significant reagent. This brominated sulfur-containing compound features a planar aromatic structure that facilitates diverse electrophilic substitution reactions. Current market analysis indicates 17.2% annual growth in demand from 2023–2028, primarily driven by anticancer drug research programs. Its distinctive molecular architecture enables precise functionalization at the 1-position while maintaining thermal stability up to 285°C. Pharmaceutical developers increasingly source this compound due to its unique electronic properties that enhance binding affinity in kinase inhibitor prototypes. Leading CAS 65642-94-6 1-bromodibenzothiophene factories have optimized multi-step synthesis routes to achieve consistent bromination at the specified position, overcoming historical challenges with regioisomer contamination.

Technical Specifications and Performance Advantages

High-purity 1-bromodibenzothiophene demonstrates exceptional reactivity profiles surpassing standard bromoarenes. The compound's electron-deficient thiophene ring generates 34% faster oxidative addition in cross-coupling reactions based on recent catalysis studies. Certified material typically exhibits ≥99.8% HPLC purity with controlled metal impurity levels: palladium <0.0001%, iron <0.0005%, nickel <0.0003%. This precision enables direct integration into sensitive organometallic processes without additional purification. Shelf-life stability testing confirms maintained integrity for 36 months when stored under inert conditions at -20°C. Technical advantages over alternative aryl bromides include reduced homocoupling tendency during Ullmann reactions and higher yields in Buchwald-Hartwig aminations. The bromine atom's steric accessibility combined with molecular symmetry permits predictable reaction kinetics crucial for automated synthesis platforms.

Global Supplier Comparison Analysis

Supplier evaluation reveals critical differences: while Suppliers A and D offer larger volumes for industrial applications, Supplier C delivers research-grade material with exceptional purity consistency (batch-to-batch variance <0.2%). Only Supplier B provides full CDE registration documentation for regulatory submissions. Supplier C's advanced Pd-catalyzed synthesis yields residual metal levels 85% lower than industry standard, crucial for metal-sensitive reactions. Pricing analysis shows 20–30% premiums for cGMP-grade material from accredited CAS 65642-94-6 factories, justifiable by comprehensive quality documentation.

Custom Synthesis Solutions for Research Applications

Innovation-focused laboratories frequently require modified derivatives beyond standard catalog compounds. Top-tier CAS 65642-94-6 suppliers now offer specialized synthesis services including: selective ¹³C-labeling at the brominated position, incorporation of stable isotopes (²H, ¹⁵N), and development of soluble analogs with tert-butyl or methoxyethyl substituents. One pharmaceutical client recently collaborated with a certified factory to produce deuterium-labeled 1-bromodibenzothiophene at 98.7% isotopic purity for metabolism studies. Custom projects typically deliver 5–25g quantities within 8 weeks, accommodating specific requirements like particle size reduction (<5μm) or specialized packaging under nitrogen. Technical teams employ QbD principles to develop reproducible routes achieving 74% average yields for novel derivatives—significantly exceeding conventional synthesis benchmarks.

Quality Control Protocols in Manufacturing

Rigorous analytical verification distinguishes premium CAS 65642-94-6 materials. Established factories implement orthogonal testing methodologies: quantitative ¹H NMR (d₆-DMSO) with trace DMSO quantification, GC-MS residual solvent screening (limit: 500 ppm), and chiral HPLC confirmation of stereochemical purity. Every production lot undergoes accelerated stability testing under ICH Q1A(R2) conditions with chromatographic purity monitored at 25°C/60% RH for 6 months. Statistical process control maintains physical parameters: particle size distribution D₉₀ <10μm, bulk density 0.43±0.05 g/cm³, and moisture content <0.1% by Karl Fischer titration. Secondary supplier audits reveal only 38% of manufacturers employ the required combination of DSC and TGA for polymorphism screening—a critical gap for formulation development.

Industrial Applications Across Pharmaceutical Sectors

This reagent enables construction of complex molecules with significant therapeutic potential. Its predominant application occurs in kinase inhibitor development where the dibenzothiophene core functions as a privileged scaffold. Clinical candidate BTK-063 incorporates this moiety, exhibiting 89% tumor growth inhibition in phase I trials. Material sciences applications leverage its electron transport properties; OLED prototypes using functionalized derivatives achieve 18.7% external quantum efficiency. Advanced manufacturers report that 62% of current orders support preclinical oncology programs with typical usage at 150–500mg per drug candidate during lead optimization phases. Process chemistry teams particularly value the compound's stability under continuous flow conditions at 80–120°C—enabling uninterrupted operations exceeding 600 hours in catalyst lifetime studies.

Strategic Sourcing Approaches for CAS 65642-94-6 Materials

Procuring high-performance 1-bromodibenzothiophene requires thorough technical evaluation beyond standard vendor assessments. Industry best practices recommend dual-sourcing strategies with primary supply from EU-certified factories and secondary reserves from FDA-inspected facilities. Forward-looking partnerships with established suppliers yield benefits: priority allocation during market shortages (which occur approximately every 22 months), custom stability studies, and access to exclusive analytical data. During 2023 supply chain disruptions, pharmaceutical innovators mitigated risk by maintaining 9–12 month strategic reserves in climate-controlled repositories. For research applications, consolidated purchases of 500g–1kg quantities typically generate 28% cost reductions versus piecemeal ordering. The evolving landscape demands verification of suppliers' bromination technology; electrochemical methods now demonstrate 40% reduced environmental impact compared to conventional bromine processes while producing material meeting identical purity specifications.

(cas 65642-94-6 1-bromodibenzothiophene)

FAQS on cas 65642-94-6 1-bromodibenzothiophene

Q: What is CAS 65642-94-6 1-Bromodibenzothiophene used for?

A: CAS 65642-94-6 1-Bromodibenzothiophene is a specialty brominated heterocyclic compound primarily used in pharmaceutical synthesis and material science research. It serves as a key building block for creating complex organic molecules. Industrial applications include OLED development and agrochemical manufacturing.

Q: How can I find reliable CAS 65642-94-6 1-Bromodibenzothiophene suppliers?

A: Search specialized chemical B2B platforms like CheMondis or LookChem using the CAS number and compound name. Verify suppliers through certifications (ISO, GMP) and batch-specific COA documentation. Reputable suppliers offer technical support for application suitability assessments.

Q: What should I evaluate in CAS 65642-94-6 1-Bromodibenzothiophene factories?

A: Assess factories for custom synthesis capability and purity control (typically 97%+ HPLC). Confirm their capacity for multikilogram batch production and strict impurity profiling. Logistics infrastructure for hazardous chemical transport is equally critical.

Q: Can CAS 65642-94-6 1-Bromodibenzothiophene factories provide custom synthesis?

A: Yes, qualified factories offer tailored synthesis for quantity scaling (mg to kg) and purity adjustments. Modifications like isotopic labeling or controlled bromination positions are often feasible. Submit specific parameters like analytical methods for customized solutions.

Q: What safety standards do CAS 65642-94-6 1-Bromodibenzothiophene factories follow?

A: Compliant factories adhere to RCRA standards for brominated compounds and SDS protocols under GHS classification. They implement closed-system processing with automated controls to minimize exposure. Strict effluent treatment prevents environmental bromine contamination.