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Oct . 02, 2024 08:05 Back to list

hydroxychloroquine sulfate cas747-36-4



Hydroxychloroquine Sulfate An Overview of Its Uses and Implications


Hydroxychloroquine sulfate, identified by its CAS number 747-36-4, is a medication primarily used to prevent and treat malaria and to manage autoimmune diseases such as rheumatoid arthritis and lupus erythematosus. As a derivative of chloroquine, hydroxychloroquine functions by altering the pH of lysosomes and the endosomal compartments within cells, thereby inhibiting the replication of viruses and modulating immune responses.


Mechanism of Action


The mechanism by which hydroxychloroquine exerts its effects is multifaceted. In treating malaria, it interferes with the parasite's ability to metabolize hemoglobin, leading to its death. In autoimmune diseases, hydroxychloroquine has been shown to decrease the activity of the immune system, which is often overactive in conditions like lupus and rheumatoid arthritis. This immunomodulatory effect helps reduce inflammation and prevents tissue damage associated with these chronic conditions.


Uses in Medicine

Hydroxychloroquine has gained significant attention beyond its traditional uses, especially during the COVID-19 pandemic. Initially, it was considered as a potential treatment for COVID-19 due to its antiviral properties. However, various studies have shown inconclusive results regarding its efficacy against the coronavirus, resulting in cautious advice from medical professionals. Despite this, the drug continues to be a staple in the treatment regimens for malaria and autoimmune disorders.


hydroxychloroquine sulfate cas747-36-4

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Dosage and Administration


Hydroxychloroquine is generally administered orally and is available in both tablet and liquid forms. The dosage varies depending on the condition being treated. For malaria prevention, the typical adult dose is 400 mg once a week. In the case of rheumatoid arthritis, starting doses are often lower to minimize side effects, with gradual adjustments made based on the patient's response to treatment.


Side Effects and Considerations


While hydroxychloroquine is generally well-tolerated, it is not without potential side effects. Common adverse effects include gastrointestinal issues such as nausea and diarrhea. More serious but rarer side effects include retinal damage, which can lead to vision problems. This risk underscores the importance of regular eye examinations for long-term users of the drug. Additionally, patients with pre-existing conditions such as cardiac issues should use hydroxychloroquine with caution, as it can affect heart rhythm.


Conclusion


In summary, hydroxychloroquine sulfate (CAS 747-36-4) remains an important medication in the treatment of malaria and autoimmune diseases. Its role during the COVID-19 pandemic has further illuminated both its potential and limits, reinforcing the need for ongoing research to clarify its effectiveness against emerging viral threats. As always, patient safety must be prioritized, requiring careful consideration of the risks and benefits associated with its use. As we move forward, hydroxychloroquine will likely continue to be a subject of interest both in clinical practice and research, underscoring the dynamic nature of pharmaceutical therapies in the evolving landscape of global health.


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