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Dec . 03, 2024 15:54 Back to list

china bicalutamide cas 90357-06-5



Understanding Bicalutamide A Comprehensive Overview


Introduction Bicalutamide, with the CAS number 90357-06-5, is an oral medication predominantly used in the treatment of prostate cancer. This non-steroidal anti-androgen is instrumental in managing advanced prostate cancer, particularly in cases where surgical castration is not feasible or undesirable. This article explores the properties, mechanism of action, therapeutic applications, side effects, and the significance of bicalutamide in cancer therapeutics.


Mechanism of Action Bicalutamide functions primarily as an androgen receptor antagonist. By competitively inhibiting the binding of androgens, such as testosterone and dihydrotestosterone, to their receptors, bicalutamide effectively reduces the growth and proliferation of prostate cancer cells, which are typically stimulated by these hormones. This action not only helps to control the progression of the disease but also assists in alleviating symptoms associated with advanced prostate cancer.


Understanding Bicalutamide A Comprehensive Overview

In some cases, bicalutamide is used off-label for conditions like hirsutism in women and as part of hormone therapy for transgender women, providing further evidence of its broad utility in various therapeutic domains.


china bicalutamide cas 90357-06-5

china bicalutamide cas 90357-06-5

Dosage and Administration Bicalutamide is commonly administered in a dose of 50 mg once daily for the treatment of prostate cancer. It is typically taken orally, with or without food, and the treatment is often continued until disease progression is observed or unacceptable toxicity occurs. It's crucial for healthcare providers to monitor patients regularly for side effects and assess the treatment's effectiveness, adjusting dosages or switching therapies as necessary.


Side Effects and Considerations While bicalutamide is generally well-tolerated, it does carry a risk of side effects. Commonly reported adverse effects include hot flashes, diarrhea, fatigue, and breast tenderness or gynecomastia due to its hormonal modulation. Serious side effects, although rare, may include liver function alterations, which necessitate regular liver enzyme monitoring during treatment.


Patients should be informed of the potential for these side effects and advised to report any unusual symptoms. Moreover, bicalutamide is contraindicated in patients with severe hepatic impairment and should be used cautiously in those with a history of liver disease.


Conclusion In conclusion, bicalutamide represents a cornerstone in the therapeutic landscape of prostate cancer management. Its ability to interfere with androgen receptor signaling aligns well with the treatment goals in androgen-sensitive malignancies. As ongoing research continues to explore new applications and combinations involving bicalutamide, its role in oncology remains significant.


For patients diagnosed with prostate cancer or related conditions, the decision to use bicalutamide should be made collaboratively between the patient and healthcare provider, considering the specific context of the disease, potential benefits, and risks. With its well-defined mechanism of action and established therapeutic utility, bicalutamide continues to be an essential agent in the fight against prostate cancer.


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