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Nov . 19, 2024 17:51 Back to list

china bicalutamide cas 90357-06-5



Bicalutamide, known by its chemical name and CAS number 90357-06-5, is a non-steroidal anti-androgen medication primarily used in the treatment of prostate cancer. This drug operates by inhibiting the action of androgens, such as testosterone, which play a critical role in the growth of prostate cancer cells. By blocking these hormones, bicalutamide can effectively slow down or prevent the advancement of the disease.

Developed in the 1970s and approved for use in many countries, bicalutamide has become a key component of prostate cancer therapy, often utilized in conjunction with other treatments such as surgical castration or luteinizing hormone-releasing hormone (LHRH) agonists. It is commonly administered in a daily oral dosage, making it a convenient option for patients.


The mechanism of action of bicalutamide involves its competition with testosterone for binding to androgen receptors on prostate cells. By occupying these receptors, bicalutamide prevents testosterone from exerting its growth-promoting effects. This action helps to induce apoptosis, or programmed cell death, in cancerous cells, decreasing the tumor burden and improving patient outcomes.


While bicalutamide is generally well-tolerated, it is not without side effects. Common adverse effects include hot flashes, gastrointestinal disturbances, and breast tenderness or gynecomastia due to hormonal changes. More serious but less common side effects can include liver dysfunction or severe allergic reactions, which warrant immediate medical attention.


china bicalutamide cas 90357-06-5

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In addition to its primary indication for prostate cancer, bicalutamide is also studied for potential use in other conditions related to androgen excess, such as hirsutism in women or as a part of hormone therapy in transgender women. However, its use in these contexts remains off-label and requires careful consideration and monitoring by healthcare professionals.


The availability of bicalutamide in the pharmaceutical market has significantly impacted prostate cancer treatment strategies, providing a valuable tool for oncologists. Moreover, ongoing research continues to explore the efficacy of bicalutamide in various therapeutic combinations and settings, aiming to improve survival rates and quality of life for patients facing prostate cancer.


In conclusion, bicalutamide (CAS 90357-06-5) represents an important advancement in the field of oncology

. Its unique mechanism of action and accessibility make it a cornerstone in the management of prostate cancer, underscoring the ongoing need for effective treatment options in the fight against this prevalent disease.


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