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Oct . 09, 2024 06:24 Back to list

wholesale tosyl chloride cas 98-59-9



Wholesale Tosyl Chloride (CAS 98-59-9) An Essential Reagent in Organic Synthesis


Tosyl chloride, also known as p-toluenesulfonyl chloride, is an important chemical compound widely utilized in organic synthesis. With the chemical formula C7H7ClO2S and a CAS number of 98-59-9, it plays a crucial role in various laboratory and industrial applications. This article will explore the properties, applications, safety considerations, and market dynamics related to wholesale tosyl chloride.


Properties of Tosyl Chloride


Tosyl chloride is a colorless to pale yellow oil with a characteristic odor. It has a molecular weight of 190.68 g/mol and a density of approximately 1.2 g/cm³. The compound is soluble in most organic solvents, including dichloromethane, chloroform, and acetone, but is insoluble in water. One of its key attributes is its ability to act as a sulfonylating agent, facilitating the transformation of alcohols and amines into their corresponding tosylates, which are more reactive.


Applications in Organic Synthesis


Tosyl chloride is a versatile reagent in organic chemistry. Here are some of its primary applications


1. Preparation of Tosylates Tosyl chloride is primarily used to convert alcohols into tosylates, which are excellent leaving groups in nucleophilic substitution reactions. The introduction of a good leaving group enhances the overall reactivity of alcohols in various synthetic pathways.


2. Protection of Alcohols and Amines In synthetic organic chemistry, tosyl chloride is often used to temporarily protect alcohols and amines. By converting these functional groups into tosylate derivatives, chemists can prevent unwanted reactions during subsequent steps of synthesis.


3. Synthesis of Sulfonamide Drugs Tosyl chloride serves as a critical building block in the preparation of sulfonamide drugs. The compound allows the introduction of sulfonamide functionalities, which are essential in medicinal chemistry for their antibacterial properties.


wholesale tosyl chloride cas 98-59-9

wholesale tosyl chloride cas 98-59-9

4. Facilitating Synthesis of Enzyme Inhibitors Researchers utilize tosyl chloride in the synthesis of various enzyme inhibitors, essential in developing pharmaceuticals aimed at targeting specific biological pathways.


Safety Considerations


While tosyl chloride is a powerful reagent, it must be handled with care. It is corrosive and can cause severe burns upon contact with skin or eyes. Additionally, the compound releases hydrogen chloride (HCl) gas upon hydrolysis, which poses respiratory hazards. Proper personal protective equipment (PPE), such as gloves, goggles, and lab coats, should always be worn when handling tosyl chloride. Furthermore, it should be stored in a cool, dry place, away from moisture and incompatible substances.


Market Dynamics and Bulk Supply


The global demand for tosyl chloride has been steadily growing, driven by its extensive applications in pharmaceutical and agrochemical sectors. Wholesale suppliers play a crucial role in meeting this demand by providing large quantities of tosyl chloride to manufacturers and research institutions. The market is characterized by a few key players who ensure the availability of high-quality tosyl chloride through various distribution channels.


When sourcing tosyl chloride, businesses should consider the supplier's reputation, product quality, and compliance with safety regulations. Suppliers often provide technical data sheets and safety data sheets to assist customers in the safe handling and application of the product.


Conclusion


Tosyl chloride (CAS 98-59-9) is an indispensable reagent in the field of organic chemistry, prized for its ability to enhance reactivity and facilitate complex synthetic transformations. Its role in drug development and other chemical applications underscores its significance in research and industry. As demand continues to grow, wholesale suppliers of tosyl chloride will remain essential partners for chemists and manufacturers seeking reliable and high-quality materials for their innovative projects.


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