A Comprehensive Overview of Tosyl Chloride (CAS 98-59-9) and Its Suppliers

Tosyl chloride, known chemically as p-toluenesulfonyl chloride, is an important sulfonyl chloride that plays a crucial role in various chemical reactions. With the CAS number 98-59-9, it is widely utilized in organic synthesis and is notable for its utility in the production of tosylates, a class of compounds that enhances the reactivity of alcohols and amines. This article explores the properties, applications, and global suppliers of tosyl chloride.

Properties of Tosyl Chloride

Tosyl chloride is a white to light yellow crystalline solid. It has a molecular formula of C7H7ClO2S and a molar mass of 190.64 g/mol. The compound is soluble in most organic solvents but exhibits limited solubility in water. Tosyl chloride is characterized by its high reactivity, especially towards nucleophiles, due to the presence of the sulfonyl group. This reactivity is predominantly exploited in converting alcohols into more reactive tosylates, which can subsequently undergo various reactions such as nucleophilic substitution or coupling reactions.

Safety precautions when handling tosyl chloride should not be overlooked, as it is a corrosive substance that can cause skin and eye irritation. Proper personal protective equipment (PPE) such as gloves, goggles, and lab coats should be used to mitigate potential hazards.

Applications of Tosyl Chloride

Tosyl chloride serves multiple applications in the field of organic chemistry

1. Preparation of Tosylates One of the most common uses of tosyl chloride is in the conversion of alcohols into tosylates. This reaction increases the leaving group ability, allowing for easier displacement reactions.

2. Synthesis of Amides and Esters Tosyl chloride can facilitate the formation of amides and esters from corresponding amines and alcohols, respectively, by providing a more reactive intermediate.

3. Protecting Group In synthetic chemistry, tosyl groups are frequently used as protecting groups for alcohols and amines, enabling chemists to selectively functionalize other parts of a molecule without interference.

4. Bioconjugation In biochemistry, tosyl chloride is utilized in bioconjugation reactions where it helps in attaching biomolecules or labels to proteins, peptides, and other biopolymers.

Given its versatility and efficiency, tosyl chloride is widely utilized across various sectors including pharmaceuticals, agrochemicals, and specialty chemicals.

Suppliers of Tosyl Chloride

With the increasing demand for tosyl chloride, a robust network of suppliers has established itself globally. Some prominent suppliers include

1. Sigma-Aldrich A leading supplier in the field of research chemicals, Sigma-Aldrich offers high-purity tosyl chloride and provides detailed product specifications and safety data sheets.

2. TCI America TCI specializes in providing high-quality chemicals for research and industrial applications. They offer tosyl chloride along with a vast range of other organic compounds.

3. Alfa Aesar A part of Thermo Fisher Scientific, Alfa Aesar supplies tosyl chloride with a focus on high-quality research chemicals and laboratory materials.

4. Acros Organics Known for its extensive catalog of organic chemicals, Acros Organics markets tosyl chloride for various chemical syntheses and industrial uses.

5. Strem Chemicals This company provides specialty chemicals, including tosyl chloride, catering to both academic and industrial customers.

When sourcing tosyl chloride, it is important to consider the supplier’s reputation, quality certifications, and adherence to regulatory standards. Customers should also inquire about shipping, handling, and safety compliance to ensure proper usage in laboratory settings.

Conclusion

Tosyl chloride (CAS 98-59-9) is a vital compound in organic chemistry, renowned for its ability to enhance the reactivity of alcohols and amines through tosylation. Its diverse applications range from synthetic organic chemistry to bioconjugation techniques, making it indispensable in various industries. With a variety of reliable suppliers available globally, acquiring high-quality tosyl chloride is essential for researchers and industrial chemists alike, ensuring the continued advancement in chemical sciences.