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Dec . 11, 2024 09:35 Back to list

Phenacetin Powder CAS 62-44-2 Overview and Applications in Pharmaceutical Industry



Phenacetin Powder (CAS 62-44-2) An Overview


Phenacetin, chemically known as acetophenetidin, is a synthetic organic compound with the molecular formula C10H13NO2. Its CAS number is 62-44-2. Historically, phenacetin was widely used as an analgesic and antipyretic agent, meaning it was commonly prescribed to alleviate pain and reduce fever. It is important to delve into its properties, uses, potential side effects, and the regulatory landscape surrounding this compound.


Chemical Properties


Phenacetin is a white to off-white crystalline powder that is relatively soluble in alcohol, ether, and hot water, but only slightly soluble in cold water. Its melting point is approximately 134-136 °C, and it has a molecular weight of 179.22 g/mol. The compound features an ethoxy group (-O-CH2-CH3) attached to an acetylaminophenol structure, which contributes to its analgesic properties.


Therapeutic Uses

In its heyday, phenacetin was used to treat a range of conditions, including headaches, muscle aches, and the common cold. It was often included in combination products with other analgesics, such as aspirin and caffeine, to enhance pain relief. However, the use of phenacetin has declined significantly due to safety concerns and the development of safer alternative medications.


Safety and Side Effects


phenacitin powder cas 62-44-2

phenacitin powder cas 62-44-2

While phenacetin was initially hailed for its effectiveness, it was later discovered to have serious side effects. Prolonged use of phenacetin has been linked to a variety of adverse effects, including kidney damage, anemia, and a potential risk for certain types of cancer, particularly bladder cancer. The compound is considered a carcinogen, and its use has been banned or severely restricted in many countries.


Reports suggest that chronic use can lead to analgesic nephropathy, a condition characterized by progressive kidney damage due to overuse of pain relievers. As a result, health authorities have placed increasing restrictions on its availability. In the United States, the FDA eventually removed phenacetin from the market in the 1980s due to its associated health risks.


Regulatory Status


Currently, phenacetin is not approved for medical use in the United States and many other countries. The regulatory stance reflects the consensus within the medical community regarding the unacceptability of its health risks compared to its therapeutic benefits. In scientific research, phenacetin is still of interest; however, it is primarily utilized in laboratory settings as a reference compound or for analytical purposes rather than as a therapeutic agent.


Conclusion


In summary, phenacetin (CAS 62-44-2) represents a critical chapter in the history of analgesic medications. Although it was once a popular treatment for pain and fever, it has since fallen out of favor due to serious safety concerns and the availability of safer alternatives. The regulatory landscape reflects a growing understanding of the risks associated with certain pharmaceuticals, emphasizing the need for ongoing research and vigilance when it comes to drug safety. As the medical community continues to prioritize patient safety, phenacetin remains a reminder of the importance of thorough evaluation in the development and approval of medication. While it may have historical significance, its place in modern medicine is now largely as a cautionary tale.


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