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Oct . 06, 2024 17:55 Back to list

phenacitin powder cas 62-44-2



Phenacitin, a chemical compound classified under the CAS number 62-44-2, is an organic substance that has garnered attention within the fields of chemistry and pharmacology. This article delves into the properties, applications, and safety considerations associated with phenacitin powder.


Chemical Properties


Phenacitin, also known as acetophenetidin or phenacetin, is an aromatic amide. Its molecular formula is C\(8\)H\(9\)NO, which illustrates its composition of carbon, hydrogen, nitrogen, and oxygen. Phenacitin appears as a white to pale yellow crystalline powder, which is both odorless and slightly soluble in water. Its melting point is around 135-137°C, making it stable under room temperature conditions. As a member of the aniline family, this compound has a structure that permits it to exhibit both analgesic and antipyretic properties.


Historical Background and Uses


Phenacitin was first introduced in the late 19th century and rapidly became popular as a pain reliever and fever reducer. Its applications included relief from headaches, muscular pain, and various other conditions causing discomfort. Phenacitin was often found in combination with other pharmaceuticals in over-the-counter medications.


Despite its effectiveness, phenacitin's popularity waned due to the discovery of harmful side effects. Regular consumption and high doses were associated with the risk of renal toxicity and nephropathy. In the mid-20th century, many countries began to restrict or withdraw phenacitin from the market, largely replaced by safer alternatives such as acetaminophen (paracetamol).


Mechanism of Action


phenacitin powder cas 62-44-2

phenacitin powder cas 62-44-2

The analgesic and antipyretic effects of phenacitin are attributed to its ability to inhibit prostaglandin synthesis. Prostaglandins are lipid compounds that play a vital role in mediating inflammatory pain and fever responses in the body. By inhibiting these compounds, phenacitin can effectively lower body temperature and alleviate pain sensations.


Safety and Regulatory Status


With the increased awareness of its potential side effects, phenacitin has come under scrutiny from health authorities. The compound is now banned or regulated in many countries due to its risks of causing serious kidney damage, particularly when used in large doses or for prolonged periods. Regulatory agencies such as the U.S. Food and Drug Administration (FDA) have issued warnings regarding the use of phenacitin. As the safety of pharmaceuticals remains a priority, substances like phenacitin are often evaluated and compared against safer alternatives in therapeutic use.


Conclusion


While phenacitin played a significant role in the history of pain management, its therapeutic use has largely diminished due to safety concerns. The compound serves as a reminder of the importance of rigorous pharmacological evaluation and monitoring of drug safety. Researchers and healthcare professionals continue to emphasize the need for safer, more effective pain relief alternatives, underscoring the progress in pharmaceutical science.


Overall, phenacitin exemplifies the dual nature of pharmaceutical development the potential for effectiveness balanced against the inherent risks of toxicology. Continued research into safer analgesics illustrates the medical community’s commitment to patient safety and well-being. As science advances, the legacy of compounds like phenacitin can inform future drug development endeavors, guiding the quest for both efficacy and safety in pain management.


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