Phenacetin (CAS 62-44-2) A Comprehensive Overview for Suppliers

Phenacetin, known by its chemical designation CAS 62-44-2, is an organic compound that has played a significant role in the pharmaceutical industry, particularly before its association with safety concerns. Originally synthesized in the late 19th century, phenacetin was widely used as an analgesic and antipyretic agent. However, due to its potential health risks, including renal damage and links to cancer, its use has diminished over the years. This article aims to provide suppliers with essential insights into phenacetin, focusing on its properties, applications, and market considerations.

Chemical Properties and Structure

Phenacetin, with the molecular formula C8H9NO2, features a p-ethoxyacetanilide structure. Its molecular weight is approximately 151.16 g/mol, and it appears as a white crystalline powder with a melting point of around 134-136 °C. It is moderately soluble in water and highly soluble in organic solvents, making it suitable for various formulations. Understanding these chemical properties is essential for suppliers when developing and marketing products containing phenacetin.

Historical Context and Usage

Phenacetin was primarily used as an over-the-counter pain reliever and fever reducer. It was popular in formulations for headaches, muscle pain, and other conditions requiring analgesia. However, due to reports of adverse effects, including nephropathy and carcinogenic risks, phenacetin has been banned or restricted in many countries. The shift in regulatory stance has led suppliers to rethink their product lines and consider alternative analgesics such as paracetamol (acetaminophen), which presents a safer profile.

Despite its decline in therapeutic use, phenacetin remains an important compound in various industrial applications. Suppliers should be aware of the following trends in the market

1. Pharmaceutical Research Phenacetin is sometimes utilized in pharmaceutical research and development. Its historical role as an analgesic offers insights into drug design, particularly in studying the mechanisms of pain relief and the development of safer alternatives.

2. Chemical Intermediates Phenacetin is used as a precursor in chemical synthesis, particularly for dyes and other organic compounds. Suppliers engaged in the chemical manufacturing sector can capitalize on this niche market opportunity.

3. Regulatory Compliance Suppliers must navigate the complex landscape of regulatory requirements surrounding phenacetin. With bans in certain regions, it is vital for suppliers to stay informed about the legal status of phenacetin in different jurisdictions. Additionally, ensuring compliance with safety data sheets (SDS) and providing proper handling instructions is crucial.

4. Shift to Safer Alternatives The increasing consumer awareness regarding health and safety has led to a demand for safer and more effective analgesics. Suppliers should consider diversifying their product offerings by exploring new compounds that provide similar therapeutic effects without the associated risks of phenacetin.

Safety and Handling

For suppliers dealing with phenacetin, understanding safety management practices is essential. Phenacetin has been classified as hazardous, necessitating the implementation of appropriate safety measures. Suppliers should provide clear guidelines for handling, storage, and disposal of phenacetin. This includes using personal protective equipment (PPE), ensuring proper ventilation in storage areas, and following local regulations regarding hazardous waste disposal.

Conclusion

Phenacetin (CAS 62-44-2) represents a complex blend of historical significance and contemporary market challenges. While its use as a pharmaceutical agent has waned due to safety concerns, opportunities still exist within research and industrial applications. Suppliers must adapt to the evolving landscape by ensuring regulatory compliance, prioritizing safety, and exploring alternative products. By doing so, they can successfully navigate the market while contributing to the ongoing quest for safer and more effective therapeutic agents. As the pharmaceutical landscape continues to evolve, staying informed and agile will be key in addressing both current demands and future challenges.