Phenacetin An Overview of CAS 62-44-2 and Its Manufacturers
Phenacetin, a compound with the Chemical Abstracts Service (CAS) registry number 62-44-2, has a long history in the pharmaceutical industry, primarily recognized for its analgesic and antipyretic properties. Once widely prescribed for pain and fever relief, its use has declined significantly due to safety concerns and the advent of safer alternatives. Despite this, phenacetin remains an important substance in certain industrial applications and research contexts.
Historical Context
Phenacetin was first synthesized in the 1880s and became a popular over-the-counter medication in the 20th century. It was marketed under various brand names and was often included in combination medications. However, in the 1970s, its use began to wane following studies that linked long-term use to serious health risks, including renal damage and potential carcinogenicity. As a result, many countries withdrew phenacetin from the market, prompting both manufacturers and consumers to seek safer alternatives.
Current Applications
Today, phenacetin is not widely used as a medication but remains relevant in certain industrial and research applications. For instance, it is still utilized in some formulations within the pharmaceutical industry for research purposes, particularly in the development of new analgesics. Additionally, phenacetin can serve as a reference standard in analytical laboratories for the assessment of drug efficacy and safety.
Manufacturers of Phenacetin
The production of phenacetin is limited to a select number of chemical manufacturers, as regulatory concerns and market demand have influenced the landscape of its production. These manufacturers typically adhere to stringent quality control measures to ensure the purity and safety of phenacetin. Here are some key factors to consider when evaluating phenacetin manufacturers
1. Quality Assurance Reputable manufacturers implement Good Manufacturing Practices (GMP) to ensure that their products meet the stringent safety and quality standards required by regulatory bodies. Quality control measures often include rigorous testing for impurities and consistency in the chemical composition of phenacetin.
2. Regulatory Compliance Manufacturers that produce phenacetin must comply with local and international regulations governing the production, handling, and distribution of chemicals. This compliance is crucial, particularly for organizations looking to use phenacetin in research or industrial applications.
3. Specialization Some manufacturers may specialize in producing phenacetin for specific applications, such as pharmaceuticals or analytical testing. Understanding the manufacturer’s expertise can help buyers select the right source for their needs.
4. Supply Chain Transparency Companies committed to transparency in their supply chains can provide valuable information about the sourcing of raw materials, production processes, and environmental impact. This transparency is particularly important for organizations focused on sustainability.
Conclusion
Despite its diminished presence in the pharmaceutical market, phenacetin (CAS 62-44-2) continues to play a role in specific industrial and research activities. Understanding the manufacturers of phenacetin is essential for those who require this compound for research or production purposes. By focusing on quality assurance, regulatory compliance, specialization, and supply chain transparency, buyers can make informed decisions when selecting a manufacturer for phenacetin. As the chemical landscape continues to evolve, the legacy of phenacetin serves as a reminder of the importance of safety and efficacy in pharmaceutical materials.