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Nov . 21, 2024 20:43 Back to list

phenacetin cas 62-44-2



Phenacetin, with the Chemical Abstracts Service (CAS) Number 62-44-2, is a synthetic compound that has attracted significant attention in the pharmaceutical realm. Established in the late 19th century, phenacetin was originally heralded for its analgesic and antipyretic properties. It is derived from acetanilide and was widely used as a pain reliever, especially for headaches, muscle aches, and fever reduction.


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However, over time, adverse effects and safety concerns have led to a decline in the use of phenacetin. Research indicated a potential link between phenacetin usage and kidney disease. Chronic consumption was associated with a form of renal damage known as analgesic nephropathy, leading to its ban in many countries starting in the 1980s.


phenacetin cas 62-44-2

phenacetin cas 62-44-2

Despite its discontinuation in mainstream medicine, the relevance of phenacetin persists in scientific research. Its metabolic pathways and the effects of its decomposition products, particularly paracetamol, continue to be subjects of study, particularly in pharmacology and toxicology. Understanding these pathways aids researchers in determining safe analgesic alternatives while maintaining effective pain management options.


Additionally, phenacetin serves as a useful chemical reagent in laboratories. Its properties allow for the synthesis of other important compounds. Researchers continue to explore its role in medicinal chemistry and its potential applications in developing new therapeutic agents.


In conclusion, while phenacetin's prominence as a medication has diminished, its historical significance and continued relevance in research underscore the compound's complex nature. As the medical community pushes towards safer analgesics, the legacy of phenacetin reminds us of the critical balance between efficacy and safety in drug development. As we advance into a new era of pharmaceutical science, the lessons learned from phenacetin and similar compounds remain invaluable.


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